Mipafox
Names | |
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Preferred IUPAC name
N,N′-Di(propan-2-yl)phosphorodiamidic fluoride | |
Other names
Bis(isopropylamino)fluorophosphine oxide; Isopestox
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Identifiers | |
3D model (
JSmol ) |
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ChEBI | |
ChemSpider | |
ECHA InfoCard
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100.006.130 |
EC Number |
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KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C6H16FN2OP | |
Molar mass | 182.179 g·mol−1 |
Density | 1.2 |
Melting point | 65 °C (149 °F; 338 K) |
Boiling point | 125 °C (257 °F; 398 K) |
80 g/L | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Highly toxic |
GHS labelling: | |
Danger | |
H301, H370 | |
P260, P264, P270, P301+P310, P307+P311, P321, P330, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mipafox is a highly toxic organophosphate insecticide that is an irreversible acetylcholinesterase inhibitor and is resistant to cholinesterase reactivators.[1] It was developed in the 1950s and is now believed to be no longer in use.[2]
Toxicity
There are case reports of delayed neurotoxicity and paralysis due to acute exposure to mipafox.[3]
Synthesis
Phosphoryl chloride is first reacted with isopropylamine. The resulting product is then reacted with potassium fluoride or ammonium fluoride to produce mipafox.[4]
See also
References
- PMID 25743373.
- ^ "The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019" (PDF). World Health Organization.
- PMID 13042137.
- ^ "Process for the preparation of bisisopropyl-amino-fluoro-phosphine oxide".