Prevotella
Prevotella | |
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Scientific classification | |
Domain: | Bacteria |
Phylum: | Bacteroidota |
Class: | Bacteroidia |
Order: | Bacteroidales |
Family: | Prevotellaceae |
Genus: | Prevotella Shah and Collins 1990 |
Species | |
See text | |
Synonyms | |
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Prevotella is a genus of Gram-negative bacteria.
Prevotella species are widely distributed across varied ecological habitats, with 57 characterized species spanning both human and other mammalian hosts.[1] In mammals, this genus is notably prevalent in the swine gut microbiome.[2]
In humans, Prevotella
Role in gut microbiota
The human gut is mainly inhabited by two
Long-term diet is reported to be associated with gut microbiome composition—those who eat protein and animal fats have predominantly Bacteroides bacteria, while those who consume more carbohydrates, especially fibre, feature Prevotella species.[8]
Prevotella is associated with gut inflammation. Increased levels of P. copri might contribute to chronic inflammation in HIV patients. Single species isolate P. copri CB7 has been reported to be beneficial or detrimental, depending on context.[4] The genus Prevotella exhibits significant genetic diversity, particularly between species associated with humans and those found in other animals. This diversity is highlighted by distinct evolutionary paths and genome sizes, with ranging base pair sizes and notable variation in G+C content. Human-related Prevotella species tend to group separately from those in animals such as swine and ruminants.[1] In addition to genetic and overall microbiota differences, Prevotella's high genetic diversity makes it difficult to predict their function, which can vary across individuals.[4]
There have also been studies uncovering the role of bacteriophages, including the discovery of megaphages in the large intestine associated with Prevotella, highlighting the potential for these phages to influence microbial populations within the host microbiome.[9]
Vaginal microbiota
Prevotella species may be commensal in the vagina, though increased abundance of Prevotella in vaginal mucosa is associated with bacterial vaginosis. A study of 542 Korean women, including identical and fraternal twins, highlighted that the vaginal microbiota's composition is influenced by menopausal status and bacterial vaginosis, with Lactobacillus and Prevotella being the most inheritable among beneficial and potentially harmful bacteria, respectively. An analysis pinpointed a genetic link between interleukin-5 variants and Prevotella abundance. Additionally, obesity was found to significantly diversify the vaginal microbiota, particularly increasing Prevotella presence. Other environmental factors like hormone therapy, human papillomavirus (HPV) infection can also influence the abundance of Prevotella.[10]
Prevotella bivia produces lipopolysaccharides and ammonia that are part of vaginal mucus. It is also associated with epithelial cytokine production and enhances the growth of other bacterial vaginosis-associated organisms, such as Gardnerella vaginalis. The latter in turn was found to stimulate growth of P. bivia.[11] P. bivia in the vaginal tract triggers an immune response similar to lipopolysaccharides, activating genes involved in the Th17 pathway (IL23A, IL6, IL1A, IL1B) through antigen-presenting cells. This activation leads to the recruitment of Th cells to the inflamed area, important for women's health since the presence of CCR5+ Th cells in the vaginal mucosa could increase HIV transmission risk during bacterial vaginosis. [12]
Pathogenicity
Prevotella intermedia and P. nigrescens are associated with inflammatory
Some studies have linked abnormal levels of Prevotella copri and rheumatoid arthritis.[16][17]
An overgrowth of Prevotella and a reduction of Lactobacillus correlated with the onset of osteomyelitis in mice. The reduction of Prevotella in model mice led to an increase of Lactobacillus showing a protection effect against osteomyelitis. Thus, changes in the Prevotella microbiota may be related to the development of osteomyelitis.[18]
Approximately 70% and 30% of Prevotella are resistant to penicillin and clindamycin, respectively, while resistance to amoxicillin/clavulanate and metronidazole is reported in less than 10% of the clinical strains responsible for bloodstream infections in humans.[19]
Species
- Prevotella albensis
- Prevotella amnii
- Prevotella bergensis
- Prevotella bivia
- Prevotella brevis
- Prevotella bryantii
- Prevotella buccae
- Prevotella buccalis
- Prevotella copri
- Prevotella dentalis
- Prevotella denticola
- Prevotella disiens
- Prevotella histicola
- Prevotella intermedia
- Prevotella maculosa
- Prevotella marshii
- Prevotella melaninogenica
- Prevotella micans
- Prevotella multiformis
- Prevotella nigrescens
- Prevotella oralis
- Prevotella oris
- Prevotella oulorum
- Prevotella pallens
- Prevotella salivae
- Prevotella stercorea
- Prevotella timonensis
- Prevotella veroralis
See also
References
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- ^ S2CID 30114888.
- PMID 2223612.
- ^ "Bacteroides Infection: Overview - eMedicine". Retrieved 2008-12-11.
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- PMID 21885731.
- PMID 30692672.
- PMID 28017660.
- PMID 30715397.
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- PMID 9657318.
- PMID 12007648.
- PMID 15183882.
- PMID 24192039.
- ^ Haridy R (2022-10-19). "New evidence linking gut bacteria with rheumatoid arthritis development". New Atlas. Retrieved 2022-10-27.
- PMID 25274309.
- S2CID 248736289.