Propiophenone

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Propiophenone
Skeletal formula of propiophenone
Ball-and-stick model of the propiophenone molecule
Names
Preferred IUPAC name
1-Phenylpropan-1-one
Other names
Ethyl phenyl ketone, BzEt
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
100.002.053 Edit this at Wikidata
UNII
  • InChI=1S/C9H10O/c1-2-9(10)8-6-4-3-5-7-8/h3-7H,2H2,1H3 checkY
    Key: KRIOVPPHQSLHCZ-UHFFFAOYSA-N checkY
  • InChI=1/C9H10O/c1-2-9(10)8-6-4-3-5-7-8/h3-7H,2H2,1H3
    Key: KRIOVPPHQSLHCZ-UHFFFAOYAT
  • CCC(=O)c1ccccc1
Properties
C9H10O
Molar mass 134.178 g·mol−1
Appearance Colorless liquid
Density 1.0087 g/mL
Melting point 18.6 °C (65.5 °F; 291.8 K)
Boiling point 218 °C (424 °F; 491 K)
Insoluble
-83.73·10−6 cm3/mol
Related compounds
Related ketones
Acetophenone
Butyrophenone
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Propiophenone (

organic solvents
. It is used in the preparation of other compounds.

Production

Propiophenone can be prepared by

alumina at 450–550 °C:[1]

C6H5CO2H + CH3CH2CO2H → C6H5C(O)CH2CH3 + CO2 + H2O

α-methoxystyrene forms this compound when heated for an hour at 300 °C (65% yield).[2][3]

Uses

appetite suppressant
.

It is an intermediate in the synthesis of the pharmaceuticals phenmetrazine and propoxyphen.[1][4][5]

Other drugs made from propiophenone include the following: PDM-35, Eprazinone, Methcathinone (leading to ephedrine), Trimebutine, Amfepramone, Diphepanol, Metamfepramone, Etoxadrol, Hydroxyphenamate, Phendimetrazine, Iminophenimide, Bencisteine, Flumecinol, Pyrroliphene, Perisone,

References