Stephen Heinemann
Stephen F. Heinemann | |
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Born | February 11, 1939 Boston, Massachusetts, US |
Died | August 6, 2014 |
Alma mater |
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Spouse | Ann Reischauer |
Children | 5 |
Scientific career | |
Fields | neuroscience |
Institutions |
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Stephen F. Heinemann (1939–2014) was a professor of
Early life
Stephen Heinemann was born February 11, 1939, in Boston, Massachusetts, to Robert Heinemann and Christel Fuchs. He grew up in
Education and career
Heinemann graduated from
Research
Stephen F. Heinemann's research focus was
Glutamate receptors
Neurological disorders
Stephen Heinemann's research contributed largely to the understanding and treatment of neurological disorders. Much of his research focused on the idea that disorders can occur when connectivity is disrupted between cells. His work with glutamate receptors showed that malfunctions can contribute to disorders such as schizophrenia and bipolar disorder.[1] In addition, he studied acetylcholine and nicotine receptors in the brain, especially their involvement with Alzheimer's and Parkinson's.[9] In doing so, his team discovered the cause of paralysis in the neuromuscular disorder, myasthenia gravis.[1]
Awards
Heinemann received a number of rewards and honors for his achievements in science. He was an elected member of the
Notable publications
Bevan S, Kullberg RW, Heinemann SF. Human myasthenic sera reduce acetylcholine sensitivity of human muscle cells in tissue culture. Nature. 267: 263–5. PMID 865619 |
Hume RI, Dingledine R, Heinemann SF. Identification of a site in glutamate receptor subunits that controls calcium permeability. Science. 253: 1028–31. PMID 1653450 |
Hollmann M, Heinemann S. Cloned glutamate receptors. Annual Review of Neuroscience. 17: 31–108. PMID 8210177 DOI: 10.1146/annurev.ne.17.030194.000335 |
Contractor A, Swanson G, Heinemann SF. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron. 29: 209–16. PMID 11182092 DOI: 10.1016/S0896-6273(01)00191-X |
Kayadjanian N, Lee HS, Piña-Crespo J, Heinemann SF. Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Molecular and Cellular Neurosciences. 34: 219–30. PMID 17174564 DOI: 10.1016/j.mcn.2006.11.001 |
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto SI, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Heinemann SF, et al. Correction to supporting information for "Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss," Proceedings of the National Academy of Sciences of the United States of America. 112: E3751-E3752. DOI: 10.1073/pnas.1511282112 |
References
- ^ a b c d e f "Stephen F. Heinemann, pioneering Salk neuroscientist, dies at 75". Salk Institute for Biological Studies. Retrieved 19 April 2019.
- ^ PMID 25436266.
- ^ a b "Stephen F. Heinemann | The Gruber Foundation". gruber.yale.edu. Retrieved 19 April 2019.
- PMID 25258411.
- ^ a b "Stephen Heinemann". www.nasonline.org. Retrieved 19 April 2019.
- ^ "The Glutamate Receptor Ion Channels -- Dingledine et al. 51 (1): 7 -- Pharmacological Reviews". 2009-02-13. Archived from the original on 2009-02-13. Retrieved 2020-03-30.
- ^ "Forget It! A Biochemical Pathway For Blocking Your Worst Fears?". ScienceDaily. 26 March 2009. Retrieved 2020-03-30.
- PMID 21256604.
- ^ "Nicotinic Receptor May Help Trigger Alzheimer's Disease". Salk Institute for Biological Studies. Retrieved 2020-03-30.