Testosterone buciclate
Clinical data | |
---|---|
Other names | Testosterone bucyclate; Testosterone 17β-buciclate; 20 Aet-1; CDB-1781; Testosterone 17β-(trans-4-butylcyclohexyl)carboxylate |
Routes of administration | Intramuscular injection |
Drug class | Androgen; Anabolic steroid; Androgen ester |
Pharmacokinetic data | |
Bioavailability | Oral: very low Intramuscular: very high |
Metabolism | Liver |
Elimination half-life | Tea seed oil: 20.9 days (i.m. )[1][2] Castor oil: 33.9 days (i.m.)[1][2] |
Excretion | Urine |
Identifiers | |
| |
JSmol) | |
| |
|
Testosterone buciclate (developmental code names 20 Aet-1, CDB-1781) is a
A single intramuscular injection of testosterone buciclate has been found to produce
Testosterone buciclate is able to reversibly and completely suppress spermatogenesis in men when used at sufficiently high dosages.[8] As such, the results of clinical studies for use of testosterone buciclate as a male contraceptive were promising, and trials continued as late as 1995,[11] but progress ultimately came to a standstill because the WHO was unable to find an industry partner willing to continue the development of the drug.[1] Because of this, the WHO backed away from testosterone buciclate and focused its research instead on testosterone undecanoate, which is also very long-lasting and has the advantage of having already been marketed and approved for medical use.[12]
Route | Medication | Major brand names | Form | Dosage |
---|---|---|---|---|
Oral | Testosteronea | – | Tablet | 400–800 mg/day (in divided doses) |
Testosterone undecanoate | Andriol, Jatenzo | Capsule | 40–80 mg/2–4x day (with meals) | |
Methyltestosteroneb | Android, Metandren, Testred | Tablet | 10–50 mg/day | |
Fluoxymesteroneb | Halotestin, Ora-Testryl, Ultandren | Tablet | 5–20 mg/day | |
Metandienoneb | Dianabol | Tablet | 5–15 mg/day | |
Mesteroloneb | Proviron | Tablet | 25–150 mg/day | |
Sublingual | Testosteroneb | Testoral | Tablet | 5–10 mg 1–4x/day |
Methyltestosteroneb | Metandren, Oreton Methyl | Tablet | 10–30 mg/day | |
Buccal | Testosterone | Striant | Tablet | 30 mg 2x/day |
Methyltestosteroneb | Metandren, Oreton Methyl | Tablet | 5–25 mg/day | |
Transdermal |
Testosterone | AndroGel, Testim, TestoGel | Gel | 25–125 mg/day |
Androderm, AndroPatch, TestoPatch | Non-scrotal patch | 2.5–15 mg/day | ||
Testoderm | Scrotal patch | 4–6 mg/day | ||
Axiron | Axillary solution | 30–120 mg/day | ||
Androstanolone (DHT) | Andractim | Gel | 100–250 mg/day | |
Rectal | Testosterone | Rektandron, Testosteronb | Suppository | 40 mg 2–3x/day |
SC ) |
Testosterone | Andronaq, Sterotate, Virosterone | Aqueous suspension | 10–50 mg 2–3x/week |
Testosterone propionateb | Testoviron | Oil solution | 10–50 mg 2–3x/week | |
Testosterone enanthate | Delatestryl | Oil solution | 50–250 mg 1x/1–4 weeks | |
Xyosted | Auto-injector | 50–100 mg 1x/week | ||
Testosterone cypionate | Depo-Testosterone | Oil solution | 50–250 mg 1x/1–4 weeks | |
Testosterone isobutyrate | Agovirin Depot | Aqueous suspension | 50–100 mg 1x/1–2 weeks | |
Testosterone phenylacetateb | Perandren, Androject | Oil solution | 50–200 mg 1x/3–5 weeks | |
Mixed testosterone esters | Sustanon 100, Sustanon 250 | Oil solution | 50–250 mg 1x/2–4 weeks | |
Testosterone undecanoate | Aveed, Nebido | Oil solution | 750–1,000 mg 1x/10–14 weeks | |
Testosterone buciclatea | – | Aqueous suspension | 600–1,000 mg 1x/12–20 weeks | |
Implant | Testosterone | Testopel | Pellet | 150–1,200 mg/3–6 months |
Notes: Men produce about 3 to 11 mg testosterone per day (mean 7 mg/day in young men). Footnotes: a = Never marketed. b = No longer used and/or no longer marketed. Sources: See template. |
Testosterone ester | Form | Route | Tmax |
t1/2 |
MRT
|
---|---|---|---|---|---|
Testosterone undecanoate | Oil-filled capsules | Oral | ? | 1.6 hours | 3.7 hours |
Testosterone propionate | Oil solution | Intramuscular injection | ? | 0.8 days | 1.5 days |
Testosterone enanthate | Castor oil solution | Intramuscular injection | 10 days | 4.5 days | 8.5 days |
Testosterone undecanoate | Tea seed oil solution | Intramuscular injection | 13.0 days | 20.9 days | 34.9 days |
Testosterone undecanoate | Castor oil solution | Intramuscular injection | 11.4 days | 33.9 days | 36.0 days |
Testosterone buciclatea | Aqueous suspension | Intramuscular injection | 25.8 days | 29.5 days | 60.0 days |
Notes: Testosterone cypionate has similar pharmacokinetics to Testosterone enanthate. Footnotes: a = Never marketed. Sources: See template. |
Medication | Form | Major brand names | Duration |
---|---|---|---|
Testosterone | Aqueous suspension | Andronaq, Sterotate, Virosterone | 2–3 days |
Testosterone propionate | Oil solution | Androteston, Perandren, Testoviron | 3–4 days |
Testosterone phenylpropionate | Oil solution | Testolent | 8 days |
Testosterone isobutyrate | Aqueous suspension | Agovirin Depot, Perandren M | 14 days |
Mixed testosterone estersa | Oil solution | Triolandren | 10–20 days |
Mixed testosterone estersb | Oil solution | Testosid Depot | 14–20 days |
Testosterone enanthate | Oil solution | Delatestryl | 14–28 days |
Testosterone cypionate | Oil solution | Depovirin | 14–28 days |
Mixed testosterone estersc | Oil solution | Sustanon 250 | 28 days |
Testosterone undecanoate | Oil solution | Aveed, Nebido | 100 days |
Testosterone buciclated | Aqueous suspension | 20 Aet-1, CDB-1781e | 90–120 days |
Nandrolone phenylpropionate | Oil solution | Durabolin | 10 days |
Nandrolone decanoate | Oil solution | Deca Durabolin | 21–28 days |
Methandriol | Aqueous suspension | Notandron, Protandren | 8 days |
Methandriol bisenanthoyl acetate | Oil solution | Notandron Depot | 16 days |
Metenolone acetate | Oil solution | Primobolan | 3 days |
Metenolone enanthate | Oil solution | Primobolan Depot | 14 days |
Note: All are via i.m. injection. Footnotes: a = TP, TV, and TUe. b = TP and TKL. c = TP, TPP, TiCa, and TD. d = Studied but never marketed. e = Developmental code names. Sources: See template. |
Androgen | Structure | Ester | Relative mol. weight |
Relative T contentb |
logPc | ||||
---|---|---|---|---|---|---|---|---|---|
Position(s) | Moiet(ies) | Type | Lengtha | ||||||
Testosterone | – | – | – | – | 1.00 | 1.00 | 3.0–3.4 | ||
Testosterone propionate | C17β | Propanoic acid |
Straight-chain fatty acid | 3 | 1.19 | 0.84 | 3.7–4.9 | ||
Testosterone isobutyrate | C17β | Isobutyric acid | Branched-chain fatty acid | – (~3) | 1.24 | 0.80 | 4.9–5.3 | ||
Testosterone isocaproate | C17β | Isohexanoic acid |
Branched-chain fatty acid | – (~5) | 1.34 | 0.75 | 4.4–6.3 | ||
Testosterone caproate | C17β | Hexanoic acid |
Straight-chain fatty acid | 6 | 1.35 | 0.75 | 5.8–6.5 | ||
Testosterone phenylpropionate | C17β | Phenylpropanoic acid | Aromatic fatty acid | – (~6) | 1.46 | 0.69 | 5.8–6.5 | ||
Testosterone cypionate | C17β | Cyclopentylpropanoic acid |
Cyclic carboxylic acid | – (~6) | 1.43 | 0.70 | 5.1–7.0 | ||
Testosterone enanthate | C17β | Heptanoic acid |
Straight-chain fatty acid | 7 | 1.39 | 0.72 | 3.6–7.0 | ||
Testosterone decanoate | C17β | Decanoic acid |
Straight-chain fatty acid | 10 | 1.53 | 0.65 | 6.3–8.6 | ||
Testosterone undecanoate | C17β | Undecanoic acid |
Straight-chain fatty acid | 11 | 1.58 | 0.63 | 6.7–9.2 | ||
Testosterone buciclated | C17β | Bucyclic acid e |
Cyclic carboxylic acid | – (~9) | 1.58 | 0.63 | 7.9–8.5 | ||
Footnotes: a = Length of Bucyclic acid = trans-4-Butylcyclohexane-1-carboxylic acid. Sources: See individual articles.
|
See also
References
- ^ ISBN 978-3-662-04491-9.
- ^ S2CID 22597244.
- ^ ISBN 978-1-85070-793-6.
- ^ ISBN 978-0967930473.
- PMID 1430080.
- ISBN 978-0-471-13320-9.
- ISBN 978-0-471-13320-9.
Testosterone buciclate is applied intramuscularly as a microcrystalline aqueous suspension. [...] After air milling [...] of crystalline testosterone buciclate to a particle size of at least 75% in the range of 10 - 50 μm, the drug was [...] suspended in sterile, aqueous suspension vehicle [...].
- ^ ISBN 978-1-59745-453-7.
- ^ ISBN 978-3-540-78355-8.
- ISBN 978-1-59259-388-0.
- PMID 7543113.
- PMID 23063338.