Testosterone undecanoate

Source: Wikipedia, the free encyclopedia.
Testosterone undecanoate
Clinical data
Pronunciation/tɛˈstɒstəroʊn ənˈdɛkənoʊeɪt/ teh-STOS-tə-rohn ən-DEK-ə-noh-ayt
Trade namesOral: Kyzatrex, Andriol, Jatenzo, others
IM: Aveed, Nebido, others
Other namesTU; Testosterone undecylate; Testosterone 17β-undecanoate; ORG-538; CLR-610
AHFS/Drugs.comMonograph
MedlinePlusa614041
License data
Pregnancy
category
Routes of
administration		By mouth, intramuscular injection
Drug classAndrogen; Anabolic steroid; Androgen ester
ATC code
Legal status
Legal status
undecanoic acid, metabolites of testosterone
Elimination half-lifeIMTooltip Intramuscular injection (in tea seed oil): 20.9 days[6][7]
IM (in castor oil): 33.9 days[6][7]
Excretion~90% Urine, 6% feces
Identifiers
  • [(8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] undecanoate
JSmol)
  • CCCCCCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
  • InChI=1S/C30H48O3/c1-4-5-6-7-8-9-10-11-12-28(32)33-27-16-15-25-24-14-13-22-21-23(31)17-19-29(22,2)26(24)18-20-30(25,27)3/h21,24-27H,4-20H2,1-3H3/t24-,25-,26-,27-,29-,30-/m0/s1 ☒N
  • Key:UDSFVOAUHKGBEK-CNQKSJKFSA-N ☒N
  (verify)

Testosterone undecanoate, sold under the brand names Andriol, Aveed and Nebido among others, is an

low testosterone levels in men,[8][6][9][10][11][12][13] It is taken by mouth or given by injection into muscle.[10][14]

testosterone ester and a prodrug of testosterone in the body.[9][8][6] Because of this, it is considered to be a natural and bioidentical form of testosterone.[16]

Testosterone undecanoate was introduced in China for use by injection and in the European Union for use by mouth in the 1970s.[17][18] It became available for use by injection in the European Union in the early to mid 2000s and in the United States in 2014.[19][20] Formulations for use by mouth are approved in the United States.[3][4][21] Along with testosterone enanthate, testosterone cypionate, and testosterone propionate, testosterone undecanoate is one of the most widely used testosterone esters.[15][6][10] However, it has advantages over other testosterone esters in that it can be taken by mouth and in that it has a far longer duration when given by injection.[22][8][6][7][10] In addition to its medical use, testosterone undecanoate is used to improve physique and performance.[10] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[10]

Oral administration of testosterone undecanoate is an effective method to achieve therapeutic physiological levels of serum testosterone in patients with hypogonadism. In addition, oral therapy has been found to have a positive impact in these patients on quality of life factors such as sexual function, mood, and mental status, as documented in various studies.[23]

Medical dosage

See also: Androgen replacement therapy § Medical uses, and Anabolic steroid § Medical

Testosterone undecanoate is used in

gluteals).[27]

Conversely, oral testosterone undecanoate must be taken two or three times a day with food.[14][28]

Side effects

See also: Anabolic steroid § Adverse effects, and Androgen replacement therapy § Adverse effects

Side effects of testosterone undecanoate include virilization among others.[10]

Anaphylaxis

The Reandron 1000 formulation (Aveed in the United States) contains 1,000 mg of testosterone undecanoate

adverse drug reactions for the Therapeutic Goods Administration (TGA), show several reports of allergic reactions since the anaphylaxis case from 2011.[medical citation needed
]

Pharmacology

Pharmacodynamics

See also: Testosterone § Mechanism of action, and Anabolic steroid § Pharmacology
Androgenic vs. anabolic activity ratio
of androgens/anabolic steroids
Medication Ratioa
Testosterone ~1:1
Androstanolone (DHT) ~1:1
Methyltestosterone ~1:1
Methandriol ~1:1
Fluoxymesterone 1:1–1:15
Metandienone 1:1–1:8
Drostanolone 1:3–1:4
Metenolone 1:2–1:30
Oxymetholone 1:2–1:9
Oxandrolone 1:3–1:13
Stanozolol 1:1–1:30
Nandrolone 1:3–1:16
Ethylestrenol 1:2–1:19
Norethandrolone 1:1–1:20
Notes: In rodents. Footnotes: a = Ratio of androgenic to anabolic activity. Sources: See template.

Testosterone undecanoate is a

anabolic–androgenic steroid (AAS). That is, it is an agonist of the androgen receptor
(AR).

Pharmacokinetics

Testosterone undecanoate has a very long

mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil.[6][7] These values are substantially longer than those of testosterone enanthate (which, in castor oil, has values of 4.5 days and 8.5 days, respectively).[31] Testosterone undecanoate is administered via intramuscular injection once every three months or so.[14][32]

Chemistry

See also: Androgen ester and List of androgen esters

Testosterone undecanoate, or testosterone 17β-undecanoate, is a

undecylate (undecanoate) ester of testosterone.[33][34] A related testosterone ester with a similarly very long duration is testosterone buciclate.[8][9]

History

In the late 1970s, testosterone undecanoate was introduced for oral use in Europe,[17] although intramuscular testosterone undecanoate had already been in use in China for several years.[18] Intramuscular testosterone undecanoate was not introduced in Europe and the United States until much later, in the early to mid 2000s and 2014, respectively.[19][20] Testosterone undecanoate was approved in the United States only in 2014 after three previous rejections due to safety concerns.[35]

Society and culture

Generic names

Testosterone undecanoate is the

generic name of the drug and its USANTooltip United States Adopted Name and BANTooltip British Approved Name.[33][34][36][37] It is also referred to as testosterone undecylate.[33][34][36][37]

Brand names

Testosterone undecanoate is or has been marketed under a variety of brand names, including Andriol, Androxon, Aveed, Cernos Depot, Jatenzo, Kyzatrex,[5] Nebido, Nebido-R, Panteston, Reandron 1000, Restandol, Sustanon 250, Undecanoate 250, and Undestor.[33][34][36][38][37]

Availability

See also: List of androgens/anabolic steroids available in the United States

Oral testosterone undecanoate is available in Europe, Mexico, Asia, and in the United States.[39][40]

Intramuscular testosterone undecanoate has approved in over 100 countries worldwide,

the USA.[10][39][41] Intramuscular testosterone undecanoate is marketed most commonly as Nebido in Europe and as Aveed in the United States while oral testosterone undecanoate is marketed most commonly as Andriol.[10][39][41] However, as of 2023 Nebido is not on the formulary of most US hospitals, due to several incidents of pulmonary embolism
that have been reported in the country.

Legal status

Testosterone undecanoate, along with other AAS, is a schedule III controlled substance in the United States under the Controlled Substances Act and a schedule IV controlled substance in Canada under the Controlled Drugs and Substances Act.[42][43]

In March 2019, the US Food and Drug Administration approved testosterone undecanoate (Jatenzo), an oral testosterone capsule to treat men with certain forms of hypogonadism. These men have low testosterone levels due to specific medical conditions, such as genetic disorders like Klinefelter syndrome or tumors that have damaged the pituitary gland.[21] The FDA granted the approval of Jatenzo to Clarus Therapeutics.[21][44]

In March 2022, testosterone undecanoate (Tlando) was approved for medical use in the United States.[4]

In July 2022, Kyzatrex, an oral testosterone undecanoate capsule, was approved for medical use in the United States.[5] The FDA granted the approval of Kyzatrex to Marius Pharmaceuticals.[45]

Research

Non-alcoholic steatohepatitis

In 2013, a

non-alcoholic steatohepatitis (NASH) was initiated in the United Kingdom.[46] In the United States in 2018, Lipocine Inc. began investigating the potential of using an oral testosterone undecanoate formulation, known as LPCN-1144, in patients with NASH.[47]

Osteoporosis

In 2013, a study aimed to evaluate the efficacy of testosterone undecanoate therapy on bone mineral density (BMD) and biochemical markers of bone turnover in elderly males with osteoporosis and low serum testosterone levels.

They study found that administering low-dose testosterone undecanoate (TU) at a rate of 20 mg per day to elderly men with low serum testosterone and osteoporosis effectively increases bone mineral density in the lumbar spine and femoral neck, and improves bone turnover, similar to the standard-dose TU (40 mg, per day) treatment. The treatment did not exhibit any adverse side effects on the prostate gland, including prostate-specific antigen. Therefore, low-dose TU appears to be a safe and cost-effective protocol for treating elderly male osteoporosis.[48] However, further clinical trials with larger sample sizes, multiple centers, and long-term follow-ups are required to determine the efficacy and safety of low-dose testosterone undecanoate treatment in elderly male osteoporosis with low serum testosterone.

Health implications

Risks associated with treatment of late-onset hypogonadism

There is a potential concern in the medical community that the administration of testosterone therapy for the treatment of late-onset hypogonadism may escalate the risks associated with benign prostatic hyperplasia, prostate cancer and heart diseases.[49]

Body composition

In 2020, a study that evaluated the effects of testosterone therapy in men with testosterone deficiency and varying degrees of weight (normal weight, overweight, and obesity) on anthropometric and metabolic parameters found that long-term testosterone undecanoate therapy in hypogonadal men, regardless of their weight at the start of the study, led to improvements in several body composition parameters, including body weight, waist circumference, and body mass index. Additionally, testosterone undecanoate therapy was found to lower fasting blood glucose and HbA1c levels and improve lipid profiles in this population.[50]

Bone density

There have been several studies that evaluate the effect of testosterone therapy on bone density or bone mineral density (BMD). One study concluded that long-term testosterone replacement therapy (TRT) in middle-aged men with late-onset hypogonadism (LOH) and metabolic syndrome (MS) led to a significant increase in both vertebral and femoral bone mineral density (BMD) after 36 months of treatment, as measured by dual-energy x-ray absorptiometry. The TRT treatment was shown to induce a 5% per year increase in BMD without changes in body mass index (BMI). The study suggests that long-term TRT could be beneficial for improving bone health in middle-aged men with LOH and MS, even in the absence of osteoporosis.[51]

References

  1. ^ "Testosterone Use During Pregnancy". Drugs.com. 20 August 2019. Archived from the original on 1 February 2014. Retrieved 18 March 2020.
  2. FDA
    . Retrieved 22 Oct 2023.
  3. ^ a b "Jatenzo- testosterone undecanoate capsule, liquid filled". DailyMed. 11 January 2021. Archived from the original on 5 January 2022. Retrieved 27 May 2022.
  4. ^ a b c "Tlando- testosterone undecanoate capsule, liquid filled". DailyMed. 28 March 2022. Archived from the original on 3 July 2022. Retrieved 27 May 2022.
  5. ^ a b c "Kyzatrex- testosterone undecanoate capsule, liquid filled". DailyMed. 18 October 2022. Retrieved 21 January 2023.
  6. ^
    ISBN 978-3-540-78355-8
    .
  7. ^
    S2CID 22597244
    .
  8. ^
    ISBN 978-1-107-01290-5. Archived
    from the original on 7 April 2022. Retrieved 3 January 2018.
  9. ^
    ISBN 978-0-7817-1750-2. Archived
    from the original on 2020-05-17. Retrieved 2018-01-03.
  10. ^
    ISBN 978-0-9828280-1-4. Archived
    from the original on 2022-07-03. Retrieved 2018-01-03.
  11. PMID 27084565
    .
  12. PMID 17635694
    .
  13. PMID 19749027
    .
  14. ^
    ISBN 978-3-8055-9569-8. Archived
    from the original on 8 November 2020. Retrieved 3 November 2016.
  15. ^
    PMID 18500378
    .
  16. PMID 27032319
    .
  17. ^
    ISBN 978-0-520-93978-3
    .
  18. ^
    ISBN 978-1-84184-749-8. Archived
    from the original on 14 April 2019. Retrieved 27 October 2017.
  19. ^
    ISBN 978-0-323-34157-8. Archived
    from the original on 14 April 2019. Retrieved 27 October 2017.
  20. ^
    S2CID 43349541
    .
  21. ^ a b c Meyer L (27 March 2019). "FDA approves new oral testosterone capsule for treatment of men with certain forms of hypogonadism" (Press release). U.S. Food and Drug Administration (FDA). Archived from the original on 7 September 2020. Retrieved 27 August 2020.
  22. S2CID 23627346
    .
  23. ^ Ahmad, Syed W et al. “Is Oral Testosterone the New Frontier of Testosterone Replacement Therapy?.” Cureus vol. 14,8 e27796. 8 Aug. 2022, doi:10.7759/cureus.27796
  24. ^ "Testosterone undecanoate depot injection". AdisInsight. Springer Nature Switzerland AG. Archived from the original on 2017-12-11. Retrieved 2017-12-11.
  25. ^ "Testosterone undecanoate - Organon". AdisInsight. Springer Nature Switzerland AG. Archived from the original on 2017-12-11. Retrieved 2017-12-11.
  26. ^ "Aveed- testosterone undecanoate injection". DailyMed. 23 August 2021. Archived from the original on 5 January 2022. Retrieved 27 May 2022.
  27. ^ https://www.bayer.com/sites/default/files/NEBIDO_EN_PIL.pdf
  28. ISBN 978-1-134-08880-5. Archived
    from the original on 3 July 2022. Retrieved 3 November 2016.
  29. PMID 22272209
    . 384054.
  30. ^ "Nebido Monograph – Information for Health Care Professionals". Bayer. 2016. Archived from the original on 19 October 2016. Retrieved 19 October 2016.
  31. ^
    ISBN 978-1-59745-453-7. Archived
    from the original on 10 November 2020. Retrieved 6 October 2016.
  32. ISBN 978-1-60795-008-0. Archived
    from the original on 2019-04-14. Retrieved 2017-10-30.
  33. ^
    ISBN 978-1-4757-2085-3. Archived
    from the original on 22 October 2020. Retrieved 6 October 2016.
  34. ^
    ISBN 978-3-88763-075-1. Archived
    from the original on 2020-01-25. Retrieved 2017-12-13.
  35. ^ Tucker ME (March 7, 2014). "FDA Approves Aveed Testosterone Jab, with Restrictions". Medscape. Archived from the original on February 1, 2017. Retrieved December 13, 2016.
  36. ^
    ISBN 978-94-011-4439-1. Archived
    from the original on 19 August 2020. Retrieved 6 October 2016.
  37. ^ a b c "Testosterone". Drugs.com. Archived from the original on 2016-11-13. Retrieved 2017-10-27.
  38. ^ "Testosterone undecanoate profile and most popular brands in USA". Downsizefitness.com. Archived from the original on 2022-07-03. Retrieved 2020-09-06.
  39. ^
    ISBN 978-3-319-46084-0
    .
  40. ISBN 978-0-12-532104-4. Archived
    from the original on 22 November 2020. Retrieved 27 October 2017.
  41. ^ a b "Drug Product Database - Health Canada". Health Canada. March 18, 2010. Archived from the original on November 19, 2016. Retrieved November 13, 2016.
  42. ISBN 978-1-4200-0346-8. Archived
    from the original on 14 April 2019. Retrieved 11 November 2017.
  43. ISBN 978-1-77172-066-3. Archived
    from the original on 14 April 2019. Retrieved 11 November 2017.
  44. ^ "Clarus Therapeutics Receives U.S. FDA Approval of Jatenzo (Testosterone Undecanoate Capsules for Oral Use) (CIII) for Testosterone Replacement Therapy in Certain Adult Men". Clarustherapeutics.com. Archived from the original on 19 February 2020. Retrieved 14 March 2022.
  45. ^ "Kyzatrex (testosterone undecanoate) FDA Approval History". Drugs.com. Retrieved 2023-04-06.
  46. ^ "Pilot Open Study of Testosterone Replacement in Non-alcoholic Steatohepatitis". Clinicaltrials.gov. 25 April 2017. Archived from the original on 9 April 2021. Retrieved 14 March 2022.
  47. ^ "Lipocine Inc. - Clinical Trials". Lipocine.com. Archived from the original on 24 May 2019. Retrieved 14 March 2022.
  48. PMID 23533404
    .
  49. PMID 35266057
    .
  50. S2CID 211102413
    .
  51. S2CID 6594250
    .
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