Tip link

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Pictures G-N show the tip links connecting the stereocilia.

Tip links are extracellular filaments that connect

protocadherin 15 and cadherin 23.[4] It has been found that the tip links are relatively stiff, so it is thought that there has to be something else in the hair cells that is stretchy which allows the stereocilia to move back and forth.[5]

It is hypothesized that the tip link is attached to the myosin motor which moves along actin filaments.[6]

See also

  • Neuronal encoding of sound

References

  1. ^ Pickles JO, Comis SD, Osborne MP. 1984.Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction. Hearing Research 15:103-112.
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  4. ^ Lewin GR, Moshourab R. 2004. Mechanosensation and pain. Journal of Neurobiology 61:30-44
  5. ^ Corey, D. Harvard University. Phone Interview. 19 November 2008.
  6. PMID 3495007
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