Trichodysplasia spinulosa polyomavirus
| Trichodysplasia spinulosa-associated polyomavirus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Monodnaviria |
| Kingdom: | Shotokuvirae |
| Phylum: | Cossaviricota |
| Class: | Papovaviricetes |
| Order: | Sepolyvirales |
| Family: | Polyomaviridae |
| Genus: | Alphapolyomavirus |
| Species: | Human polyomavirus 8 |
| Virus: | Trichodysplasia spinulosa-associated polyomavirus
|
| Synonyms | |
| |
Trichodysplasia spinulosa polyomavirus (also known as Trichodysplasia spinulosa-associated polyomavirus, abbreviated TSPyV or TSV) is a
polyomavirus to be discovered, and one of four associated with human disease, out of 13 human polyomaviruses known as of the 2015 update to polyomavirus taxonomy released by the International Committee on Taxonomy of Viruses.[4][5][6]
Structure and genome
Like all polyomaviruses, TSPyV has a circular
tumors. The same study also observed evidence of an additional protein, called tiny T, and of an alternatively spliced form of large tumor antigen known as ALTO.[7]
Clinical manifestations
neoplasia.[13] TSPyV appears to actively replicate in the hair follicle inner root sheath cells; hyperproliferation of these cells is thought to underlie the clinically observable manifestations of the disease.[9][13] Antiviral drugs such as valganciclovir and cidofovir have shown benefit in treating this disorder in case reports.[14][15]
Epidemiology
As with most human polyomaviruses, TSPyV is a common asymptomatic infection in healthy adults. Estimates of
immunocompromised individuals, and then only in a small minority of those in whom the virus is detectable. Individuals with TS symptoms exhibit much higher viral loads than do asymptomatically infected immunocompromised individuals.[2][9]
References
- ^ "Genus: Alphapolyomavirus" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 17 June 2019.[dead link]
- ^ PMID 20686659.
- S2CID 42096048.
- ^ ICTV. "Virus Taxonomy: 2015 Release". Retrieved 26 July 2016.
- PMID 26923930.
- PMID 23474680.
- ^ PMID 26136575.
- PMID 25291363.
- ^ S2CID 13734654.
- S2CID 26367357.
- PMID 10674379.
- S2CID 29925028.
- ^ PMID 22196870.
- PMID 19103376.
- PMID 22351821.
- PMID 21801610.
- PMID 26667254.