WU polyomavirus

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Human polyomavirus 4
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Sepolyvirales
Family: Polyomaviridae
Genus: Betapolyomavirus
Species:
Human polyomavirus 4

WU polyomavirus (also known as WU virus, WUPyV, or Human polyomavirus 4) is a virus of the family Polyomaviridae. It was discovered in 2007 in samples of human respiratory secretions, originally from a child patient in Australia who presented with clinical signs of pneumonia and in whom other common respiratory viruses were not detected. Follow-up studies identified the presence of WU virus in respiratory secretion samples from patients in Australia and the United States, suggesting that, like other human polyomaviruses, WU virus is widely distributed.[1]

Discovery

WU virus was discovered by

KI virus.[2]

Genome

Genome structure of the WU virus.[1]

The complete

double-stranded DNA genome of 5229 base pairs containing genetic material characteristic of polyomaviruses, encoding five viral proteins: three capsid components, major capsid protein VP1, VP2, and VP3; and two additional proteins involved in replication, the large tumor antigen and small tumor antigen.[1]

Prevalence

Although WU virus has been detected in a variety of locations around the world, indicating a global distribution, estimates of its prevalence vary. In the first report describing the virus, its DNA was detected in 0.7% of respiratory secretion samples in a population in

maternal antibodies against both WU and KI.[5] A 2016 study of polyomavirus seroprevalence found WU virus in 97.4% of samples from another American population.[6] Primary infection is generally believed to occur in childhood.[6]

Disease association

WU virus was originally discovered in respiratory secretions from a patient diagnosed with

immunocompromised patients.[10]

Nomenclature and classification

WU virus got its name from

JC virus and BK virus. A 2010 proposed classification recommended the division of the polyomaviruses into three genera, containing one genus of avian viruses and two of mammalian viruses; one of the latter was designated Wukipolyomavirus to indicate its two founding members.[11] In an updated classification system for the polyomavirus family proposed in 2016, WU virus is classified as a member of the genus Betapolyomavirus along with BK, JC, and KI.[8]

References

  1. ^
    PMID 17480120
    .
  2. PMID 17287263
    .
  3. ^
    PMID 18573691
    .
  4. PMID 19325891
    .
  5. PMID 19751580
    .
  6. ^
    PMID 26667254
    .
  7. PMID 17997354
    .
  8. ^
    PMID 26923930
    .
  9. PMID 23357733
    .
  10. S2CID 38133334
    .
  11. PMID 21562881
    .
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