ABCB5
| ABCB5 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 7: 20.62 – 20.78 Mb | Chr 12: 118.83 – 118.93 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene.[5][6] ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.[7][8][9]
Clinical significance
ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma, colorectal cancer, and malignant pleural mesothelioma. It is commonly over-expressed on circulating melanoma tumour cells.shRNA knockdown experiments.[12]
In colorectal cancer, ABCB5 was shown to act as a mediator of
paracrine interactions between the cancer stem cells and tumor bulk population (in a rheostat manner termed "cancer stem cell rheostasis").[14][15] ABCB5 was shown to maintain the slow-cycling melanoma stem cells using this cytokine signaling loop, which became more differentiated upon ABCB5 interference (e.g. WFDC1 melanocyte differentiation marker increased, cancer cells were faster growing in vitro, tumors were more pigmented), or CXCR1 blockade (slow-cycling ABCB5+ cells entered the cell-cycle).[15]
In normal physiology, ABCB5 is a functional marker for adult limbal stem cells of the cornea. ABCB5+ cells could regrow a human cornea on a mouse with limbal stem cell deficiency (LSCD - a blindness disease of the corneal limbus) while ABCB5- cells could not, indicating a therapeutic potential for treating some types of blindness. ABCB5 was further shown to be anti-apoptotic in these adult stem cells.[16]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000004846 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072791 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8894702.
- PMID 12960149.
- PMID 15760339.
- PMID 15899824.
- PMID 19725928.
- PMID 18202660.
- PMID 20977885.
- PMID 21212411.
- PMID 21652540.
- ^ Milosevic, V. et al. Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer, https://doi.org/10.1002/ijc.32419
- ^ PMID 24934811.
- PMID 25030174.
Further reading
- Milosevic V, et al. (January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5". Int. J. Cancer. 146 (1): 192–207. S2CID 160014053.
- Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM (December 2009). "Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma". Pigment Cell & Melanoma Research. 22 (6): 740–9. PMID 19725928.
- Corrocher R, Tedesco F, Rabusin P, De Sandre G (February 1975). "Effect of human erythrocyte stromata on complement activation". British Journal of Haematology. 29 (2): 235–41. S2CID 45491647.
- Frank NY, Frank MH (October 2009). "ABCB5 gene amplification in human leukemia cells". Leukemia Research. 33 (10): 1303–5. PMID 19477512.
- Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM (April 2005). "Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes". Pigment Cell Research. 18 (2): 102–12. PMID 15760339.
- Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadée W (June 2004). "Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance". Cancer Research. 64 (12): 4294–301. PMID 15205344.
- Malorni W, Lucia MB, Rainaldi G, Cauda R, Cianfriglia M, Donelli G, Ortona L (January 1998). "Intracellular expression of P-170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients". Haematologica. 83 (1): 13–20. PMID 9542318.
- Matalon ST, Drucker L, Fishman A, Ornoy A, Lishner M (February 2008). "The Role of heat shock protein 27 in extravillous trophoblast differentiation". Journal of Cellular Biochemistry. 103 (3): 719–29. S2CID 8249760.
- Begley GS, Horvath AR, Taylor JC, Higgins CF (January 2005). "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome". Molecular Immunology. 42 (1): 137–41. PMID 15488952.
- Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (November 2010). "A genome-wide study reveals copy number variants exclusive to childhood obesity cases". American Journal of Human Genetics. 87 (5): 661–6. PMID 20950786.
- Fukunaga-Kalabis M, Martinez G, Nguyen TK, Kim D, Santiago-Walker A, Roesch A, Herlyn M (November 2010). "Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population". Oncogene. 29 (46): 6115–24. PMID 20729912.
- Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST (January 2011). "Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance". Gastroenterology. 140 (1): 344–55. PMID 20682318.
- Yang JY, Ha SA, Yang YS, Kim JW (2010). "p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance". BMC Cancer. 10: 388. PMID 20649952.
- Sharma BK, Manglik V, Elias EG (September 2010). "Immuno-expression of human melanoma stem cell markers in tissues at different stages of the disease". The Journal of Surgical Research. 163 (1): e11–5. PMID 20638684.
- Gazzaniga P, Cigna E, Panasiti V, Devirgiliis V, Bottoni U, Vincenzi B, Nicolazzo C, Petracca A, Gradilone A (December 2010). "CD133 and ABCB5 as stem cell markers on sentinel lymph node from melanoma patients". European Journal of Surgical Oncology. 36 (12): 1211–4. PMID 20573479.
- Ma J, Frank MH (February 2010). "Tumor initiation in human malignant melanoma and potential cancer therapies". Anti-Cancer Agents in Medicinal Chemistry. 10 (2): 131–6. PMID 20184545.
- Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH (January 2010). "Modulation of T-cell activation by malignant melanoma initiating cells". Cancer Research. 70 (2): 697–708. PMID 20068175.
External links
- ABCB5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ABCB5 human gene location in the UCSC Genome Browser.
- ABCB5 human gene details in the UCSC Genome Browser.