Alpha-v beta-3
αVβ3 is a type of
dendritic cells.[2]
As a drug target
Integrin αVβ3 is a potential drug target because abnormal expression of v3 is linked to the development and progression of various diseases. Its role in angiogenesis, in cancer and other diseases, is linked to the blood supply for problematic overgrowths.[3]
Inhibitors like
antiangiogenics.[4]
One novel protein (ProAgio) has been designed to bind at an unusual site, and then induces apoptosis by recruiting caspase 8.[3] It is designed by mutating domain 1 of CD2 (D1-CD2), which naturally binds weakly to the receptor.[5]
RGD motif that αVβ3 recognizes. A high-affinity, pure antagonist mutant has been discovered for this protein.[6]
See also
- Proteases in angiogenesis
- Vitaxin, a respective antibody
References
External links
- integrin+alphaVbeta3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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