ITGAE
| ITGAE | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 3.71 – 3.8 Mb | Chr 11: 72.98 – 73.04 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an
CD49d
).
Tissue distribution
CD103 is expressed widely on
mesenteric lymph nodes, known as CD103 dendritic cells, also expresses this marker.[9]
It is useful in identifying
enteropathy-associated T cell lymphoma.[10]
Function
The chief ligand for αEβ7 is
E-cadherin, a cellular adhesion molecule (CAM) found on epithelial cells.[11] It is probably important for T cell homing to the intestinal sites[12] and thymocyte contacts with thymic reticuloepithelial cells.[13]
Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of
CD103
and have been attributed regulatory activity. It is unclear whether the presence of CD103 on Treg cells represents a specialized feature for Treg, or Treg differentiation of IEL T cells.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000083457 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005947 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 12370249.
- ^ "Entrez Gene: integrin".
- PMID 12242333.
- S2CID 22884381.
- PMID 16216890.
- ISBN 978-92-832-2431-0.
- PMID 9378961.
- PMID 10978890.
- S2CID 14571087.
- PMID 17137867.
Further reading
- Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. PMID 20237496.
- Tilburgs T, Scherjon SA, Roelen DL, Claas FH (2009). "Decidual CD8+CD28- T cells express CD103 but not perforin". Hum. Immunol. 70 (2): 96–100. PMID 19150377.
- Schlickum S, Sennefelder H, Friedrich M, et al. (2008). "Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion". Blood. 112 (3): 619–25. PMID 18492951.
- Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. PMID 20379614.
- Liu YH, Chen RH, Chen WC, et al. (2010). "Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients". Ophthalmology. 117 (8): 1645–51. PMID 20417566.
- Lesch KP, Timmesfeld N, Renner TJ, et al. (2008). "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies". J Neural Transm. 115 (11): 1573–85. S2CID 7036114.
- Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. PMID 17975119.
- Agace WW, Higgins JM, Sadasivan B, et al. (2000). "T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines". Curr. Opin. Cell Biol. 12 (5): 563–8. PMID 10978890.
- Hadley G (2004). "Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells". Am. J. Transplant. 4 (7): 1026–32. S2CID 3038018.
- Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. PMID 19074885.
- Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. PMID 19023099.
- Silva LK, Blanton RE, Parrado AR, et al. (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. PMID 20588308.
- Annacker O, Coombes JL, Malmstrom V, et al. (2005). "Essential role for CD103 in the T cell-mediated regulation of experimental colitis". J. Exp. Med. 202 (8): 1051–61. PMID 16216886.
- Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. PMID 12370249.
- Uss E, Rowshani AT, Hooibrink B, et al. (2006). "CD103 is a marker for alloantigen-induced regulatory CD8+ T cells". J. Immunol. 177 (5): 2775–83. PMID 16920912.
- Le Floc'h A, Jalil A, Vergnon I, et al. (2007). "Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis". J. Exp. Med. 204 (3): 559–70. PMID 17325197.
- Heron M, Grutters JC, Van Moorsel CH, et al. (2009). "Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography". Clin. Immunol. 133 (1): 117–25. PMID 19604725.
- Shaw SK, Brenner MB (1995). "The beta 7 integrins in mucosal homing and retention". Semin. Immunol. 7 (5): 335–42. PMID 8580465.
- Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins". Cell. Mol. Life Sci. 54 (6): 556–66. S2CID 9775686.
- Heron M, Slieker WA, Zanen P, et al. (2008). "Evaluation of CD103 as a cellular marker for the diagnosis of pulmonary sarcoidosis". Clin. Immunol. 126 (3): 338–44. PMID 18182176.
External links
- ITGAE+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGAE Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine