CD2

CD2
Gene ontology
Molecular function	protein homodimerization activity protein binding signaling receptor binding signaling receptor activity antigen binding protein kinase binding receptor tyrosine kinase binding protein self-association
Cellular component	integral component of membrane membrane cell-cell junction anchored component of plasma membrane integral component of plasma membrane extracellular region cell surface cytoplasmic side of plasma membrane external side of plasma membrane plasma membrane protein-containing complex membrane raft
Biological process	positive regulation of myeloid dendritic cell activation heterotypic cell-cell adhesion natural killer cell activation membrane raft polarization cell surface receptor signaling pathway cell adhesion positive regulation of tumor necrosis factor production T cell activation leukocyte migration regulation of T cell differentiation apoptotic process cell-cell adhesion
Sources:Amigo / QuickGO

Ensembl				ENSG00000116824	ENSMUSG00000027863
UniProt	P06729 Q53F96	P08920
RefSeq (mRNA)	NM_001767 NM_001328609	NM_013486
RefSeq (protein)	NP_001315538 NP_001758 NP_001758.2	NP_038514
Location (UCSC)	Chr 1: 116.75 – 116.77 Mb	Chr 3: 101.18 – 101.2 Mb
PubMed search	[3]	[4]

Wikidata

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CD2 (cluster of differentiation 2) is a

. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,^[5] LFA-3 receptor, erythrocyte receptor and rosette receptor.^[6]

Function

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.^[7]

In addition to its adhesive properties, CD2 also acts as a

Diagnostic relevance

CD2 is a specific marker for T cells and NK cells, and can therefore be used in

Classification

Due to its structural characteristics, CD2 is a member of the

Interactions

CD2 has been shown to

References

Further reading

• Sayre PH, Reinherz EL (1989). "Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review". Scand. J. Rheumatol. Suppl. 76: 131–44.
  PMID 2471997
  .
• Rouleau M, Mollereau B, Bernard A, Metivier D, Rosenthal-Allieri MA, Charpentier B, Senik A (1997). "CD2 induced apoptosis of peripheral T cells". Transplant. Proc. 29 (5): 2377–8.
  PMID 9270771
  .
• Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1–2): 1–14.
  PMID 11602341
  .
• Yang JJ, Ye Y, Carroll A, Yang W, Lee HW (2002). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr. Protein Pept. Sci. 2 (1): 1–17.
  PMID 12369898
  .
• Bell GM, Seaman WE, Niemi EC, Imboden JB (1992). "The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line". J. Exp. Med. 175 (2): 527–36.
  PMID 1346273
  .
• Marie-Cardine A, Maridonneau-Parini I, Ferrer M, Danielian S, Rothhut B, Fagard R, Dautry-Varsat A, Fischer S (1992). "The lymphocyte-specific tyrosine protein kinase p56lck is endocytosed in Jurkat cells stimulated via CD2". J. Immunol. 148 (12): 3879–84.
  PMID 1351089
  .
• Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE (1992). "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59". Science. 256 (5065): 1805–7.
  PMID 1377404
  .
• Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3): 307–14.
  PMID 1385321
  .
• Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13.
  PMID 1832084
  .
• Schraven B, Samstag Y, Altevogt P, Meuer SC (1990). "Association of CD2 and CD45 on human T lymphocytes". Nature. 345 (6270): 71–4.
  S2CID 23605689
  .
• Samelson LE, Fletcher MC, Ledbetter JA, June CH (1990). "Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase". J. Immunol. 145 (8): 2448–54.
  PMID 1976695
  .
• Luzzati AL, Pugliese O, Giacomini E, Giordani L, Quintieri F, Hraba T, Mach O, Krchnák V, Vágner J (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1): 71–7.
  PMID 2111780
  .
• Seed B, Aruffo A (1987). "Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3365–9.
  PMID 2437578
  .
• Peterson A, Seed B (1987). "Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)". Nature. 329 (6142): 842–6.
  S2CID 4315968
  .
• Sayre PH, Chang HC, Hussey RE, Brown NR, Richardson NE, Spagnoli G, Clayton LK, Reinherz EL (1987). "Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2941–5.
  PMID 2883656
  .
• Diamond DJ, Clayton LK, Sayre PH, Reinherz EL (1988). "Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes". Proc. Natl. Acad. Sci. U.S.A. 85 (5): 1615–9.
  PMID 2894031
  .
• Lang G, Wotton D, Owen MJ, Sewell WA, Brown MH, Mason DY, Crumpton MJ, Kioussis D (1988). "The structure of the human CD2 gene and its expression in transgenic mice". EMBO J. 7 (6): 1675–82.
  PMID 2901953
  .
• Leca G, Boumsell L, Fabbi M, Reinherz EL, Kanellopoulos JM (1986). "The sheep erythrocyte receptor and both alpha and beta chains of the human T-lymphocyte antigen receptor bind the mitogenic lectin (phytohaemagglutinin) from Phaseolus vulgaris". Scand. J. Immunol. 23 (5): 535–44.
  S2CID 84246845
  .
• Sewell WA, Brown MH, Dunne J, Owen MJ, Crumpton MJ (1986). "Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen". Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8718–22.
  PMID 3490670
  .

External links

• CD2+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Mouse CD Antigen Chart
• Human CD Antigen Chart
• Human CD2 genome location and CD2 gene details page in the UCSC Genome Browser.