Alverine
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Alverine is a drug used for
Adverse effects
The side effects of alverine include:[1][2]
- Difficulties in breathing or shortness of breath, wheezing, swelling of the face or other parts of the body (associated with serious allergic reaction)
- Yellowing of the whites of the eyes and the skin, due to liver inflammation
- A feeling of nausea or dizziness
- Headache
- Minor allergic reaction (skin rash/itching)
It was reported that alverine may induce toxic hepatitis.[3][4]
Mechanism of action
Alverine acts directly on the muscle in the gut, causing it to relax. Alverine is a 5HT1A antagonist, which reduces rectal hypersensitivity.
Alverine capsules[7] are now available in the market. There are two strengths of capsule - 60 mg and 120 mg. The common dosage for adults and children over 12 years is 60–120 mg taken one, two or three a day, either before or after meals. Alverine is not suitable for those aged under 12 years. Women who are pregnant or breast-feeding should follow the instruction of doctors for the drug.
Development and marketing
A combination of alverine citrate and simeticone (ACS) for irritable bowel syndrome therapy were compared with placebo in a phase IV clinical trial.[8] At week 4, the alverine citrate and simeticone group had lower VAS scores for abdominal pain/discomfort (median: 40 mm vs. 50 mm, P = 0.047) and higher responder rate (46.8% vs. 34.3%, OR = 1.3; P = 0.01) as compared with the placebo group.[9]
The drug was firstly authorized for marketing on 03/06/2014. The marketing authorisation holder is Dr. Reddy's Laboratories (UK) Ltd.[10]
References
- ^ "Alverine capsules - Spasmonal, Audmonal. Side effects; dosage | Patient". Patient. Retrieved 2015-12-06.
- ^ "Alverine Citrate Patient Information Leaflet" (PDF). Medicines.org.uk. 2014. Archived from the original (PDF) on 2017-12-01.
- PMID 16378311. Archived from the original(PDF) on 2018-11-23.
- PMID 15259090.
- PMID 11697552.
- ^ "Detailed Info About Irritable bowel syndrome". Retrieved 2017-07-26.
- ^ "Alverine Citrate 60 mg Hard Capsules". Drugs.com. Retrieved 2015-12-06.
- ^ Clinical trial number NCT00542295 for "Efficacy and Safety of Meteospasmyl® in Irritable Bowel Syndrome" at ClinicalTrials.gov
- S2CID 35881469.
- ^ "Alverine citrate 60 mg hard capsules - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Retrieved 2015-12-06.