Camylofin

Source: Wikipedia, the free encyclopedia.
Camylofin
Clinical data
Other namesAcamylophenine
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • Isopentyl 2-[2-(diethylamino)ethylamino]-2-phenylacetate
JSmol)
  • O=C(OCCC(C)C)C(NCCN(CC)CC)c1ccccc1
  • InChI=1S/C19H32N2O2/c1-5-21(6-2)14-13-20-18(17-10-8-7-9-11-17)19(22)23-15-12-16(3)4/h7-11,16,18,20H,5-6,12-15H2,1-4H3 ☒N
  • Key:RYOOHIUJEJZCFT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Camylofin is an

antimuscarinic drug.[1]

Camylofin is a

pyrexia.[2]

Synthesis

Synthesis:[3][4] Patents:[5][6][7] Metamizole salt patents:[8][9][10]

The Hell–Volhard–Zelinsky halogenation on phenylacetic acid [103-82-2] (1) gives 2-Bromo-2-phenylacetyl bromide, CID:15621041 (2). Treatment with isoamyl alcohol [123-51-3] gives 3-methylbutyl bromo(phenyl)acetate [92018-48-9] (3). Alkylation with N,N-Diethylethylenediamine [100-36-7] (4) completed the synthesis of Camylofin (5).

References

  1. ^ "Camylofin". PubChem. Retrieved 2019-06-02.
  2. PMID 24179892
    .
  3. ^ Bruzzese, Tiberio; Crescenzi, Elda (1966). "N-Aminoalkyl-α-aminoacids and Their Corresponding Ethyl Esters". Journal of Pharmaceutical Sciences. 55 (7): 737–740. doi:10.1002/jps.2600550717.
  4. ^ Szarvasi, E. et al, Bull. Soc. Chim. Fr., 1957, 1019.
  5. ^ Brock Norbert, Kuhas Engelbert, & Schmeisser Martin, U.S. patent 2,665,300 (1954 to Asta Medica AG).
  6. ^ Martin Dr-Chem Schmeisser, Engelbert Dr Phil Kuehas, Norbert Dr Med Brock, DE842206 (1952 to Asta Werke Ag Chem Fab).
  7. ^ , GB688331 (1953 to Asta Medica AG).
  8. ^ , GB782068 (1957 to Asta Medica AG).
  9. ^ Kuhas Engelbert, Brock Norbert, & Arnold Herbert, CA566251 (1958 to Asta Medica AG).
  10. ^ Arnold Herbert, Kuhas Engelbert, & Brock Norbert, U.S. patent 2,857,395 (1958).
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