Cisapride
Clinical data | |
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Trade names | Prepulsid, Propulsid |
AHFS/Drugs.com | FDA Professional Drug Information |
MedlinePlus | a694006 |
Pregnancy category |
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Routes of administration | By mouth (tablets), suspension |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 30-40% |
Protein binding | 97.5% |
Metabolism | liver CYP3A4, intestinal |
Elimination half-life | 10 hours |
Excretion | kidney, bile duct |
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Cisapride is a
The commercial preparations of this drug are the
Medical uses
Cisapride has been used for the treatment of gastroesophageal reflux disease (GERD). There is no evidence it is effective for this use in children.[5] It also increases gastric emptying in people with diabetic gastroparesis. Evidence for its use in constipation is not clear.[6]
In many countries, it has been either withdrawn or had its indications limited because of reports of the side-effect
Veterinary uses
Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to treat megacolon in cats.
Cisapride is also commonly used to treat GI stasis in rabbits, sometimes in conjunction with metoclopramide (Reglan).
Kinetics
Oral bioavailability of cisapride is approximately 33%. It is inactivated primarily by hepatic metabolism by CYP3A4 with a half-life of 10 hours. The dose of the drug should be reduced in case of liver diseases.[9]
Pharmacology and mechanism of action
As a
See also
- Domperidone
- Drug of last resort
- Serotonin-agonising laxatives
- Benzamide
- Itopride
- Metoclopramide
- Mosapride
References
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ "Propulsid To Go Off Market - Warning". MedicineNet. Retrieved 2021-12-25.
- ^ "PROPULSID: A Heartburn Drug, Now Linked to Children's Deaths". Los Angeles Times. 2000-12-20. Retrieved 2021-12-25.
- ^ US patent 5955478, Gray NM, Young JW, "Methods for treating gastrointestinal motility dysfunction using optically pre (+) cisapride", issued 1999-Sep-21
- ^ PMID 20393933.
- PMID 21249695.
- ^ ""Cardiac contraindications included in new FDA warnings about Propulsid"". medscape.com. January 25, 2000. Retrieved 10 May 2021.
- ^ "Drugs banned in India". Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Archived from the original on 2015-02-21. Retrieved 2013-09-17.
- S2CID 33641651.
Further reading
- Brenner GM (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6.
- Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4.
- "Cisapride". Medline Plus. U.S. National Library of Medicine.