Angiolymphoid hyperplasia with eosinophilia

Angiolymphoid hyperplasia with eosinophilia
Other names	Epithelioid hemangioma
Angiolymphoid hyperplasia with eosinophilia
Specialty	Dermatology

Angiolymphoid hyperplasia with eosinophilia (also known as:^[1] "Epithelioid hemangioma," "Histiocytoid hemangioma," "Inflammatory angiomatous nodule," "Intravenous atypical vascular proliferation," "Papular angioplasia," "Inflammatory arteriovenous hemangioma," and "Pseudopyogenic granuloma") usually presents with pink to red-brown, dome-shaped, dermal papules or nodules of the head or neck, especially about the ears and on the scalp.^[2]

It, or a similar lesion, has been suggested as a feature of IgG4-related skin disease, which is the name used for skin manifestations of IgG4-related disease.^[3][4]

Signs and symptoms

Angiolymphoid hyperplasia with eosinophilia is characterized by papulonodular lesions on the head and neck that are violaceous or erythematous.^[5] Lesions on the genital area, upper limbs, and trunk are uncommon. The lesions could be painful, pruriginous, or asymptomatic. Peripheral eosinophilia and lymphadenomegaly could be present.^[6]

Causes

Currently, the cause of angiolymphoid hyperplasia with eosinophilia is unknown. Several theories have been proposed, but none of them have proven to be conclusive or definitive. These include reactive processes, neoplastic processes, and infectious mechanisms that may be connected to the

While angiolymphoid hyperplasia with eosinophilia is thought to be a benign tumefaction, it has been linked to a number of lymphoproliferative disorders, which lends credence to the argument put forth by some that angiolymphoid hyperplasia with eosinophilia could occasionally be a monoclonal T-cell process.^[14][15] Follic mucinosis was found to be present concurrently in a small number of angiolymphoid hyperplasia with eosinophilia cases.^[16] A clear correlation between angiolymphoid hyperplasia with eosinophilia and mycosis fungoides has not yet been documented, and this association is fairly ambiguous.^[7] Remarkably, a patient with angiolymphoid hyperplasia with eosinophilia has been documented to develop peripheral T-cell lymphoma.^[17] T-cell receptor gene (TCR) rearrangement and monoclonality have also been found in angiolymphoid hyperplasia with eosinophilia cases.^[14][15] The same monoclonal TCR gene rearrangement was found in both lesions in a patient, who had both peripheral T-cell lymphoma and angiolymphoid hyperplasia with eosinophilia.^[15]

Diagnosis

A complete blood count, which is part of the laboratory analysis, indicates peripheral blood eosinophilia in about 20% of the cases.^[8]

To make the diagnosis, a biopsy of the lesions is needed. Strong reactivity for CD31 and lower reactivity for CD34 and factor VIII-related antigen is shown by an immunohistochemical analysis.^[18]

When angiolymphoid hyperplasia with eosinophilia lesions are examined under a microscope, a polymorphous vascular pattern made up of uniformly spaced linear and dotted vessels is visible over a background that ranges in color from pink to red.^[19]

Treatment

The preferred course of treatment is surgical excision; after being fully removed, angiolymphoid hyperplasia with eosinophilia rarely returns.^[20] Other treatments include cryosurgery,^{[citation needed]} carbon dioxide laser,^[21] pulsed-dye laser,^[22] and Mohs micrographic surgery.^[23]

See also

• Kimura's disease
• List of cutaneous conditions

References