Arthur Pardee

Source: Wikipedia, the free encyclopedia.
Arthur Beck Pardee
Born(1921-07-13)July 13, 1921
DiedFebruary 24, 2019(2019-02-24) (aged 97)
NationalityAmerican
CitizenshipAmerican
EducationBachelor of Science degree from the University of California, Berkeley (1942)
Master's degree from California Institute of Technology (1943)
PhD degree from California Institute of Technology (1947)
Alma materUniversity of California, Berkeley
Known forPaJaMo Experiment
AwardsPfizer Award in Enzyme Chemistry (1960)
Sir Hans Krebs Medal (1973)
Rosenstiel Award (1974)
Scientific career
FieldsMolecular biology
InstitutionsDana–Farber Cancer Institute; Harvard Medical School

Arthur Beck Pardee (July 13, 1921 – February 24, 2019) was an American biochemist. One biographical portrait

tumor growth and regulation, with a particular focus on the role of estrogen in hormone-responsive tumors. He is also well known for the development of various biochemical research techniques, most notably the differential display methodology, which is used in examining the activation of genes in cells. More recently he championed the acceptance and adoption of the conceptual review as a valuable approach to unearthing new knowledge from the enormous stores of information in the scientific literature. He died in February 2019 at the age of 97.[3]

Career

Pardee received his Bachelor of Science degree from the

National Academy of Sciences in 1968,[6] and the American Philosophical Society in 2001.[7]

PaJaMo

While on sabbatical in Paris with Jacob and Monod, Pardee was involved in an experiment that became known as PaJaMo.

ribosomes, which turned over too slowly to enable the rapid synthesis seen in PaJaMo. On 15 April 1960, Jacob discussed the PaJaMo experiment's findings with Sydney Brenner and Francis Crick at King's College, Cambridge. This caused Brenner and Crick to formulate on the spot the hypothesis that yet another RNA species existed, messenger RNA.[9]

Feedback Inhibition

With his student Richard Yates, Pardee discovered that biosynthesis of

metabolic regulation. Feedback inhibition in glycolysis had been reported by Zacharias Dische in an almost unknown paper a decade earlier.[11][12]

The restriction point

In the early 1970s Pardee identified that the cell cycle has a point in the 'G1 phase' where the cell, as it were, 'commits' to moving to the 'S phase'. Pardee published on this so-called 'restriction point', sometimes called the 'Pardee point', in 1974.[13]

Students

Pardee's students included Allan Wilson, who gained his PhD at Berkeley under Pardee's supervision in 1961. Monica Riley was also a Ph.D. student with Pardee and contributed to his studies of mRNA.

References

  1. PMID 12429915
    .
  2. PMID 24853970
    .
  3. ^ Arthur B. Pardee
  4. ^ "About Us". World Cultural Council. Retrieved November 8, 2016.
  5. ^ "Arthur Beck Pardee". American Academy of Arts & Sciences. Retrieved 2021-10-15.
  6. ^ "Arthur B. Pardee". www.nasonline.org. Retrieved 2021-10-15.
  7. ^ "APS Member History". search.amphilsoc.org. Retrieved 2021-10-15.
  8. PMID 24853970
    .
  9. ISBN 9780465091379
    .
  10. PMID 13357469
    .
  11. ^ Dische, Z. (1941). "Sur l'interdépendance des divers enzymes du système glycolytique et sur la régulation automatique de leur activité dans les cellules". Bull. Soc. Chim. Biol. 23: 1140–1148.
  12. S2CID 227948364
    .
  13. PMID 4524638
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Arthur_Pardee&oldid=1187182676"