Gregory Petsko

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Greg Petsko
ThesisStructural studies of triose phosphate isomerase. (1974)
Doctoral advisorDavid Chilton Phillips
WebsiteOfficial website

Gregory A. Petsko (born August 7, 1948) is an American

Weill Cornell Medical College and is still an adjunct professor of Biomedical Engineering at Cornell University, and is also the Gyula and Katica Tauber Professor, Emeritus, in biochemistry and chemistry at Brandeis University. On October 24, 2023, in a ceremony in the East Room of the White House, President Joe Biden presented Gregory Petsko and eight others with the National Medal of Science
, the highest honor the United States can bestow on a scientist and engineer.

As of 2020 Petsko's research interests are understanding the

.

Education

Petsko was an undergraduate at Princeton University, where he graduated summa cum laude in 1970. He received a Rhodes Scholarship, and obtained his doctorate in Molecular Biophysics from Merton College, Oxford supervised by David Phillips, studying the structure and mechanism of the enzyme triosephosphate isomerase. [1]

He did a brief postdoctoral fellowship in Paris with

Guggenheim Foundation Fellowship.[2]

Career

President Joe Biden awards the National Medal of Science to Professor Gregory A. Petsko of Harvard Medical School and Brigham & Women's Hospital on October 24, 2023. Photo by Jay Premack/USPTO.

Petsko's independent academic career has included stints at

Weill Cornell Medical College as the director of the Helen and Robert Appel Alzheimer's Disease Research Institute and the Arthur J. Mahon Professor of Neurology and Neuroscience in the Feil Family Brain and Mind Research Institute, and at Cornell University as adjunct professor of Biomedical Engineering, and retained an appointment at Brandeis University as Gyula and Katica Tauber Professor of Biochemistry and Chemistry, Emeritus.[4][5] His wife was named president and CEO of the Dana–Farber Cancer Institute in October 2016, and in January 2019 he followed her back to Boston, assuming his present position as Professor of Neurology at the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital and Harvard Medical School. On October 24, 2023, he and eight other scientists received the National Medal of Science from President Joe Biden. The National Medal of Science is the highest honor the United States can confer on a scientist; since the first was awarded in 1963 by President John F. Kennedy, only 506 individuals have received it.[3][4][5][6]

Research

Petsko's current research interests are understanding the

biochemical bases of neurological diseases like Alzheimer's, Parkinson's, and ALS, discovering drugs (especially by using structure-based drug design) that could therapeutically affect those biochemical targets, and seeing any resulting drug and gene therapy candidates tested in humans.[5][6]

Petsko's past research interests

enzymology. He is co-author with Dagmar Ringe of Protein Structure and Function.[8] He was also the author of a monthly column in Genome Biology[9][10] modelled after an amusing column in Current Biology penned by Sydney Brenner.[11] The first ten years of that column are available as an eBook.[12]

Petsko is best known for his collaborative work with Dagmar Ringe, in which they used X-ray crystallography to solve important problems in protein function including protein dynamics as a function of temperature and problems in mechanistic enzymology,[13][14][15] and for his collaborative work with Dr. Scott Small of Columbia University, which focuses on the retromer endosomal protein trafficking pathway and its role in Alzheimer's and Parkinson's diseases.[16][17][18][19][20][21][22][23][24]

At MIT and Brandeis, he and Dagmar Ringe trained a large number of current leaders in structural molecular biology who now have leadership roles in science. These individuals include:

References

  1. ^ Bailey, Melissa (2016-03-01). "Recruited to lead Harvard med, 'fearless' scientist chose Dana-Farber". STAT. Retrieved 2023-01-02.
  2. ^ "Biochemist Greg Petsko elected to American Philosophical Society".
  3. ^ Tate Herbert for The Justice November 13, 2012 Petsko set to leave University for New York City in 2014
  4. ^ Weill Cornell Newsroom. April 16, 2014 No Stone Unturned: Interview with Gregory Petsko
  5. ^ a b Petsko Laboratory Homepage
  6. ^ Columbia University Newsroom. April 20, 2014 'Chaperone' compounds offer new approach to Alzheimer's treatment
  7. Microsoft Academic
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  12. ^ Petsko, Gregory (2010-10-10). Gregory Petsko in Genome Biology: The first 10 years. BioMed Central.
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