Bodybuilding supplement

Source: Wikipedia, the free encyclopedia.

Bodybuilding supplements are

HMB, whey protein, ZMA, and weight loss products.[1][2]
Supplements are sold either as single ingredient preparations or in the form of "stacks" – proprietary blends of various supplements marketed as offering synergistic advantages.

History

Athletes in ancient Greece were advised to consume large quantities of meat and wine. A number of herbal concoctions and tonics have been used by strong men and athletes since ancient times across cultures to try to increase their strength and stamina.[3]

In the 1910s,

consomme) as a way to enhance muscle recovery. In the 1950s, with recreational and competitive bodybuilding becoming increasingly popular, Irvin P. Johnson began to popularize and market egg
-based protein powders marketed specifically at bodybuilders and physical athletes. The 1970s and 1980s marked a dramatic increase in the growth of the bodybuilding supplement industry, fueled by the widespread use of modern marketing techniques and a marked increase in recreational bodybuilding.

In October 1994, the

Dietary Supplement Health and Education Act (DSHEA) was signed into law in the USA. Under DSHEA, responsibility for determining the safety of the dietary supplements changed from the government to the manufacturer, and supplements no longer required approval from the U.S. Food and Drug Administration (FDA) before distributing the products. Since that time, manufacturers did not have to provide FDA with the evidence to substantiate safety or effectiveness unless a new dietary ingredient was added. It is widely believed that the 1994 DSHEA further consolidated the position of the supplement industry and lead to additional product sales.[4]

Protein

Further information: Protein quality and Protein supplement
Protein shakes, made from protein powder (center) and milk (left), are a common bodybuilding supplement.

protein for reasons of convenience, lower cost (relative to meat and fish products), ease of preparation, and to avoid the concurrent consumption of carbohydrates and fats. Additionally, some argue that bodybuilders, by virtue of their unique training and goals, require higher-than-average quantities of protein to support maximal muscle growth.[5][6][7][8][9][10][11][12] While the recommended dietary allowance is much less,[13] Harvard Medical School points out in Health Health Publishing that this RDA (recommended daily allowance) is “the minimum amount you need to keep from getting sick — not the specific amount you are supposed to eat every day.”[14] Protein supplements are sold in ready-to-drink health shakes, bars, meal replacement products (see below), bites, oats, gels and powders. Protein powders are the most popular and may have flavoring added for palatability. The powder is usually mixed with water, milk or fruit juice and is generally consumed immediately before and after exercising or in place of a meal. The sources of protein are as follows and differ in protein quality
depending on their amino acid profile and digestibility:

  • branched-chain amino acids. It also has the highest content of the amino acid cysteine, which aids in the biosynthesis of glutathione. For bodybuilders, whey protein provides amino acids used to aid in muscle recovery.[15] Whey protein is derived from the process of making cheese from milk. There are three types of whey protein: whey concentrate, whey isolate, and whey hydrolysate. Whey concentrate is 29–89% protein by weight whereas whey isolate is 90%+ protein by weight. Whey hydrolysate is enzymatically predigested and therefore has the highest rate of digestion of all protein types.[15]
  • Casein protein (or milk protein) has glutamine, and casomorphin.[15]
Shaker Bottle commonly used to mix supplements. Often has mesh or a metal whisk inside to breakdown lumps in the mixture.

Some nutritionists have suggested that higher calcium excretion may be due to a corresponding increase in protein-induced calcium absorption in the intestines.[16][17][18]

Amino acids

Some bodybuilders believe that amino acid supplements may benefit muscle development, but consumption of such supplements is unnecessary in a diet that already includes adequate protein intake.[19]

Prohormones

Main article: Androgen prohormone

An androgen prohormone, or proandrogen, is a

DHEA sulfate (DHEA-S), and androstenedione may all be considered proandrogens of testosterone.[20]

Since 2005, the use of steroid precursors (prohormones) has been illegal in the U.S.[21]

Creatine

Main article:
Creatine supplements

creatine phosphate replenishment of ATP. Scientific studies have shown that creatine supplementation can increase the consumer's strength,[23] energy during performance,[24] muscle mass, and recovery times after exercise. In addition, recent studies have also shown that creatine improves brain function.[25] and reduces mental fatigue.[26]

Some studies have suggested that consumption of creatine with protein and carbohydrates can have a greater effect than creatine combined with either protein or carbohydrates alone.[27]

While generally considered safe, long-term or excessive consumption of creatine may have an adverse effect on the

kidneys, liver, or heart and should be avoided if any pre-existing conditions affecting these organs exist.[28]

β-Hydroxy β-methylbutyrate

Main article:
Beta-Hydroxy beta-methylbutyric acid

When combined with an appropriate exercise program, dietary supplementation with

mechanistic target of rapamycin (mTOR) and inhibition of the proteasome in skeletal muscles.[31][34]

The inhibition of exercise-induced skeletal muscle damage by HMB is affected by the time that it is used relative to exercise.[29][33] The greatest reduction in skeletal muscle damage from a single bout of exercise appears to occur when calcium HMB is ingested 1–2 hours prior to exercise.[33]

Controversy

Mislabeling and adulteration

While many of the claims are based on scientifically-based physiological or biochemical processes, their use in bodybuilding parlance is often heavily colored by bodybuilding lore and industry marketing and, as such, may deviate considerably from traditional scientific usages of the terms. In addition, ingredients listed have been found at times to be different from the contents. In 2015, Consumer Reports reported unsafe levels of arsenic, cadmium, lead, and mercury in several of the protein powders that were tested.[35]

In the United States, the manufacturers of dietary supplements do not need to provide the Food and Drug Administration with evidence of product safety prior to marketing.

designer steroids with unknown safety and pharmacological effects has increased.[38][39]

In 2015, a CBC investigative report found that protein spiking (i.e., the addition of amino-acid filler to manipulate analysis) was not uncommon;[40] however, many of the companies involved challenged these claims.[40]

Health problems

The US FDA reports 50,000 health problems a year due to dietary supplements

N,alpha-Diethylphenylethylamine, a methamphetamine analog.[43]

The incidence of liver damage from herbal and dietary supplements is about 16–20% of all supplement products causing injury, with the occurrence growing globally over the early 21st century.[2] The most common liver injuries from weight loss and bodybuilding supplements involve hepatocellular damage and jaundice. The most common supplement ingredients attributed to these injuries are catechins from green tea, anabolic steroids, and the herbal extract, aegeline.[2] Other products by supplement designer and CEO of Driven Sports, Matt Cahill, have contained dangerous substances causing blindness or liver damage, and his pre-workout supplement Craze was found to contain illegal stimulants[44] that resulted in several athletes failing drug tests.[45]

Protein effectiveness

Some have argued that there is little evidence to indicate any benefit to using bodybuilding protein or amino acid supplements. A 2005 overview concluded that "[i]n view of the lack of compelling evidence to the contrary, no additional dietary protein is suggested for healthy adults undertaking resistance or endurance exercise".[13]

In contrast, a 2018 systematic review, meta-analysis and meta-regression concluded that, “Dietary protein supplementation significantly enhanced changes in muscle strength and size during prolonged RET in healthy adults.“ (RET is an abbreviation for resistance exercise training.)[46]

See also

Notes

  1. 3-methylhistidine.[29][32][33] When exercise intensity and volume are sufficient to cause skeletal muscle damage, such as during long-distance running or progressive overload, HMB supplementation has been demonstrated to attenuate the rise in these biomarkers by 20–60%.[29][33]

References

  1. PMID 28554316. Archived
    from the original on 2021-07-29. Retrieved 2021-07-29.
  2. ^
    PMID 27677775
    .
  3. ISBN 978-0-415-86279-0
    .
  4. JSTOR 27840828
  5. S2CID 16708689. Archived
    (PDF) from the original on 2016-03-04. Retrieved 2012-01-10.
  6. S2CID 14586881
    .
  7. PMID 17213878
    .
  8. PMID 18577776
    .
  9. S2CID 8141005
    .
  10. S2CID 16708689
    .
  11. S2CID 33218998
    .
  12. S2CID 27679614
    .
  13. ^
    ISBN 978-0-309-08525-0. Archived
    from the original on 2019-08-14. Retrieved 2017-01-01.
  14. ^ https://www.health.harvard.edu/blog/how-much-protein-do-you-need-every-day-201506188096#:~:text=The%20Recommended%20Dietary%20Allowance%20(RDA,meet%20your%20basic%20nutritional%20requirements. Harvard Medical School , Harvard Health Publishing. “How much protein do you need every day?” Reviewed by Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing. June 22, 2023.
  15. ^
    PMID 10919959
    .
  16. PMID 12936953
    .
  17. PMID 12612169
    .
  18. PMID 15001604
    .
  19. ISBN 978-0-17-650258-4
    .
  20. ISBN 978-0-444-51830-9
    .
  21. ^ Friedel, Angelika, et al. "17β-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties." Toxicology letters 165.2 (2006): 149-155.
  22. ISSN 0731-5724
    .
  23. PMID 10731009
    .
  24. S2CID 8455503
    .
  25. PMID 14561278
    .
  26. S2CID 6304255
    .
  27. PMID 8944667
    .
  28. ^ "Creatine". Mayo Clinic. Archived from the original on 2020-12-09. Retrieved 2020-12-16.
  29. ^
    S2CID 45124293
    . Wilson et al. [91] demonstrated that when non-resistance trained males received HMB pre-exercise, the rise of lactate dehydrogenase (LDH) levels reduced, and HMB tended to decrease soreness. Knitter et al. [92] showed a decrease in LDH and creatine phosphokinase (CPK), a byproduct of muscle breakdown, by HMB after a prolonged run. ... The utility of HMB does seem to be affected by timing of intake prior to workouts and dosage [97].
  30. ^
    PMID 26169182
    .
  31. ^
    S2CID 29717535. Archived
    (PDF) from the original on 2021-11-24. Retrieved 2020-09-01. In conclusion, HMB treatment clearly appears to be a safe potent strategy against sarcopenia, and more generally against muscle wasting, because HMB improves muscle mass, muscle strength, and physical performance. It seems that HMB is able to act on three of the four major mechanisms involved in muscle deconditioning (protein turnover, apoptosis, and the regenerative process), whereas it is hypothesized to strongly affect the fourth (mitochondrial dynamics and functions). Moreover, HMB is cheap (~30– 50 US dollars per month at 3 g per day) and may prevent osteopenia (Bruckbauer and Zemel, 2013; Tatara, 2009; Tatara et al., 2007, 2008, 2012) and decrease cardiovascular risks (Nissen et al., 2000). For all these reasons, HMB should be routinely used in muscle-wasting conditions especially in aged people. ... 3 g of CaHMB taken three times a day (1 g each time) is the optimal posology, which allows for continual bioavailability of HMB in the body (Wilson et al., 2013).
  32. ^
    S2CID 22657268
    . HMB, a derivative of leucine, prevents muscle damage and increases muscle strength by reducing exercise-induced proteolysis in muscles and also helps in increasing lean body mass. ... The meta analysis studies and the individual studies conducted support the use of HMB as an effective aid to increase body strength, body composition, and to prevent muscle damage during resistance training.
  33. ^
    PMID 23374455
    .
  34. PMID 26010896
    .
  35. ^ McGinn D (7 November 2010). "Are protein shakes the weight-loss magic bullet? - The Globe and Mail". Theglobeandmail.com. Archived from the original on 2 June 2016. Retrieved December 11, 2015.
  36. ^ a b "Body-building Products and Hidden Steroids: Enforcement Barriers". Food and Drug Administration. Archived from the original on 2015-03-14.
  37. ^ O'Connor A (21 December 2013). "Spike in Harm to Liver Is Tied to Dietary Aids". The New York Times. Archived from the original on 10 April 2019. Retrieved 26 February 2017.
  38. PMID 26074745
    .
  39. PMID 33371574
    .
  40. ^ a b Griffith-Greene M (13 November 2015). "M Some protein powders fail fitness test". Marketplace. CBC News. Archived from the original on 8 September 2017. Retrieved 11 December 2015.
  41. ^ Offit PA, Erush S (14 December 2013). "Skip the Supplements". The New York Times. Archived from the original on 17 July 2019. Retrieved 26 February 2017.
  42. ^ "Tainted Body Building Products". U.S. Food and Drug Administration. 17 December 2010. Archived from the original on 23 April 2019. Retrieved 16 December 2019.
  43. ^ Young A (25 October 2013). "Popular sports supplements contain meth-like compound". USA Today. Archived from the original on 12 November 2019. Retrieved 24 August 2017. Cohen said researchers informed the FDA in May about finding the new chemical compound in Craze. The team found the compound — N,alpha-diethylphenylethylamine — has a structure similar to methamphetamine, a powerful, highly addictive, illegal stimulant drug. They believe the new compound is likely less potent than methamphetamine but greater than ephedrine.
  44. ^ "Driven Sports Inc. - 04/04/2014". U.S. Food and Drug Administration. 2019-12-20. Archived from the original on 2021-01-22. Retrieved 2020-12-16.
  45. ^ Young A (27 September 2013). "Sports supplement designer has history of risky products". USA Today. Archived from the original on 25 June 2019. Retrieved 24 August 2017.
  46. ^ Morton, Robert W., et al. "A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults." British journal of sports medicine 52.6 (2018): 376-384.

External links

Wikimedia Commons has media related to Bodybuilding supplements.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Bodybuilding_supplement&oldid=1219214279"