Epithelial-myoepithelial carcinoma of the lung
Epithelial-myoepithelial carcinoma of the lung | |
---|---|
Other names | EMECL Adenomyoepithelioma,[1] Myoepithelioma, Epithelial-myoepithelial tumor, Epimyoepithelial carcinoma, Malignant mixed tumor containing epithelial and myoepithelial cells.[2] |
Specialty | Oncology |
Epithelial-myoepithelial carcinoma of the lung is a very rare
Genetics
The epithelial component in EMECL's typically strongly express
Diagnosis
Microscopically, EMECL features bi-layered glandular or ductular structures consisting of inner
The histologic appearance of these tumors varied, but all shared the common feature of a biphasic proliferation of
Classification
The WHO-2004 scheme groups lung carcinomas into 8 major types:[2]
- Squamous cell carcinoma
- Small cell carcinoma
- Adenocarcinoma
- Large cell carcinoma
- Adenosquamous carcinoma
- Sarcomatoid carcinoma
- Carcinoid tumor
- Salivary gland-like carcinoma
EMECL is considered a subtype of salivary gland-like carcinoma, tumors so named because their histological appearance and characteristics closely resemble malignant neoplasms arising in the major and minor
Staging
EMECL is staged in the same manner as other non-small cell lung carcinomas, based on the TNM (Tumor-Node-Metastasis) staging system.[8]
Treatment
Complete radical
Prognosis
The prognosis of EMECL is relatively good, and considerably better than most other forms of NSCLC. The skull and dura are possible sites for metastasis from pulmonary EMC. The MIB-1 index is a predictive marker of malignant potential.[citation needed]
Incidence
EMECL is extremely rare, with only a handful of cases reported in the literature.[11]
In the lung, two salivary gland-like carcinomas, mucoepidermoid carcinoma and adenoid cystic carcinoma, while extremely uncommon, occur far more often than does EMECL.[2][12]
References
External links
- "Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart". World Health Organization Classification of Tumours. (Download Page).
- [1] National Library of Medicine
- "Lung cancer page". National Cancer Institute. 1 January 1980.