Giant-cell glioblastoma

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Giant-cell glioblastoma
WHO Classification
Standard nameGiant-cell glioblastoma
StructureNeuroepithelial tumors
└►Astrocytic tumors
└►Glioblastoma
└►Giant-cell glioblastoma
ICD-O Code & WHO Grade
ICD-O Code9441/3
WHO GradeIV
Synonyms & Acronyms
SynonymsMonstrocellular sarcoma
Epidemiology
Incidence0.15/100,000/y
new cases/population/year
Age peak42
M/F ratio1.6
Prognosis
Mean overall survival12 months
Medicine WikiProject/Neurology task force

The giant-cell glioblastoma is a

histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells
.

It occasionally shows an abundant

gene mutations.[1][2]

Symptoms and signs are similar to those of the ordinary glioblastoma. Methodology of diagnosis and treatment are the same.

Prognosis is similar to the ordinary glioblastoma, which is approximately 12 months,[3] although some authors refer to cases with a slightly better outcome.[4][5][6][7][8]

Historical annotation

The giant-cell glioblastoma was originally termed monstrocellular sarcoma, because of its stromal reticulin network,

GFAP expression analysis.[11][12][13]

Epidemiology

Incidence

The giant-cell glioblastoma is a rare neoplasia: its incidence is less than 1% of all brain tumors. It represents up to 5% of glioblastomas.[14]

Age and sex distribution

The mean age at clinical presentation is 42. The age distribution includes children and has a wider range than other diffuse

WHO grade II astrocytoma, anaplastic astrocytoma, ordinary glioblastoma).[14][15][16]

The giant-cell glioblastoma affects males more frequently (the M/F ratio is 1.6).[1]

Prognosis

Most patients with giant-cell glioblastoma have unfavourable prognosis,[17] but some authors report clinical results slightly better than the ordinary glioblastoma,[8][7][6][5][4] in all probability because this variant seems less infiltrative, due to the nature of giant cells of this type.[1]

See also

References

  1. ^
    ISBN 92-832-2409-4.[page needed
    ]
  2. ISBN 88-299-1739-7.[page needed
    ]
  3. ^ DeAngelis LM, Loeffler JS, Adam N, Mamelak AN (2007). "Primary and Metastatic Brain Tumors". In Pazdur R, Coia LR, Hoskins WJ, Wagman LD (eds.). Cancer Management: A Multidisciplinary Approach (10th ed.). Retrieved 4 August 2009.[page needed]
  4. ^
    PMID 9694343
    .
  5. ^
    PMID 6260329
    .
  6. ^
    PMID 6018784
    .
  7. ^
    PMID 15309911
    .
  8. ^
    PMID 2912529
    .
  9. OCLC 6845931.[page needed
    ]
  10. ISBN 978-0-387-10933-6.[page needed
    ]
  11. PMID 216839
    .
  12. ISBN 978-3-540-56971-8.[page needed
    ]
  13. ^ Russell DS, Rubinstein LJ (1989). Pathology of Tumors of the Nervous System (5th ed.). London: Edward Arnold.[page needed]
  14. ^
    PMID 2718792
    .
  15. PMID 9284834
    .
  16. PMID 9370234
    .
  17. PMID 8916121
    .
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