Grape seed extract

Source: Wikipedia, the free encyclopedia.
Not to be confused with grapefruit seed extract.

Grape seed extract is an industrial derivative of whole

astringent sensation in the mouth.[4]

Extraction method

The properties of grape seed extract depend on the extraction process used to obtain it and how the grapes were grown. The classic method incorporates extraction with organic solvents such as

proton NMR spectroscopy with principal component analysis to ensure accurate composition.[5]

Supplement use and research

Grape seed extract is sold as a dietary supplement.[1] Oral administration of grape seed extract (dose and frequency unreported) was well tolerated in people over 14 weeks.[1] Side effects may include itchy scalp, dizziness, headache, and nausea.[1]

A 2019

LDL cholesterol, total cholesterol, triglycerides, and the inflammatory marker, C-reactive protein.[1] However, each of the studies was small in size, possibly affecting interpretation of the analysis.[1]

A 2016 meta-analysis concluded that grape seed extract, in a dose of under 800

diastolic blood pressure.[6] People with metabolic syndrome had a more significant outcome (average of a 8½ mmHg decrease in systolic blood pressure) than in healthy subjects.[6] The authors concluded that heterogeneity in the study designs and small sample sizes involved in the meta-analysis introduced uncertainty in the results, and that larger-scale, long-term, multiple-dose studies in people with high blood pressure were warranted.[6]

Cancer

Grape seed extract has been incorrectly described as a cancer cure on social media websites.[7] There is no clinical evidence that grape seed extract is effective to treat cancer.[8] In 2017, the Food and Drug Administration listed grape seed extract as a fake cancer cure that consumers should avoid.[9]

References

  1. ^ a b c d e f "Grape Seed Extract". National Center for Complementary and Integrative Health, US National Institutes of Health. February 2025. Retrieved 24 March 2025.
  2. PMID 29651231
    .
  3. PMID 26417310
    .
  4. ISSN 0308-8146
    .
  5. ^
    PMID 22489164
    .
  6. ^
    PMID 27537554
    .
  7. ^ Wade, Natalie (2022). "Facebook posts falsely tout grape seeds as proven cancer cure". AFP Fact Check. Archived from the original on June 27, 2022.
  8. ^ "Does a diet rich in grapes prevent and treat cancer?". Cancer Council Australia. 2024. Archived from the original on May 29, 2024.
  9. ^ "187 Fake Cancer "Cures" Consumers Should Avoid". Food and Drug Administration. 2017. Archived from the original on May 2, 2017.
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