Guanadrel

Source: Wikipedia, the free encyclopedia.
Guanadrel
Names
IUPAC name
2-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
IUPHAR/BPS
KEGG
MeSH C004945
UNII
  • InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13) ☒N
    Key: HPBNRIOWIXYZFK-UHFFFAOYSA-N ☒N
  • InChI=1/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13)
    Key: HPBNRIOWIXYZFK-UHFFFAOYAB
  • C1CCC2(CC1)OCC(O2)CN=C(N)N
Properties
C10H19N3O2
Molar mass 213.281 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Guanadrel is an

antihypertensive agent.[1] It is used in the form of its sulfate
.

Mechanism of action

Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the

sympathetic nerve stimulation, as a result of catecholamine depletion, leads to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position. Guanadrel is rapidly and well absorbed from gastrointestinal tract.[2]

In 1981 the

JAMA reported guanadrel as an effective step II or step III treatment of hypertension.[3]

References

  1. PMID 4031111.[permanent dead link
    ]
  2. ^ Guanadrel, from Pharmacogenetics Knowledge Base
  3. PMID 7206175
    .

External links
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