Hexamethonium
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Hexamethonium is a non-depolarising
Pharmacology
By blocking the neuronal nicotinic receptors in autonomic ganglia, which are necessary for transmission in all autonomic ganglia, both the sympathetic and parasympathetic nervous systems are inhibited. Its action on the neuronal nicotinic receptors is primarily through the block of the ion pore, rather than through competition with the binding site for acetylcholine.[3]
Postganglionic sympathetic systems are usually regulated by norepinephrine (noradrenaline) (adrenergic receptors), whereas parasympathetic systems are acetylcholine-based, and instead rely on muscarinic receptors (some post-ganglionic sympathetic neurons, such as those stimulating sweat glands, release acetylcholine).
The organ system and adverse effects of
Uses
It was formerly used to treat disorders, such as chronic hypertension, of the peripheral nervous system, which is innervated only by the sympathetic nervous system. The non-specificity of this treatment led to discontinuing its use.[4]
The use of inhaled hexamethonium, an unapproved drug, in a normal volunteer during a medical study is believed to have caused or contributed to her death
See also
References
- ^ "Hexamethonium - Compound Summary". PubChem. U.S. National Library of Medicine. 2013-06-18.
- ^ Howland RD, Mycek MJ (2006). Lippincott's illustrated reviews: Pharmacology (3rd ed.). p. 47.
- PMID 6146366.
- ISBN 978-0071354691.
- ^ Perkins E (August 7, 2001). "Johns Hopkins' Tragedy: Could Librarians Have Prevented a Death?". Information Today, Inc. Retrieved 2008-10-06.
- PMID 11834748.