Healing of periapical lesions
The body's response to microbial invasion
In response to tissue
Soon after inflammation has been initiated,
When
Breakthrough in bacteriology
In 1890, W.D. Miller, considered the father of oral
Moreover, it has since been discovered that endodontic infections are polymicrobial. In fact, the bacteria present within endodontic infections are thoroughly similar to the bacteria that are involved in periodontal disease. It has also been shown that certain enzymes produced by bacteria are detrimental to the host, and can work in concert with the destructive capability of the enzymes released by dying neutrophils. Recent studies have revealed that the gene for collagenases could be detected in stains of Porphyromonas gingivalis, one of the many endodontic infective agents that are also involved in periodontal disease.[13]
Additionally, it has been proven that a positive correlation exists between the number of bacteria in an infected root canal and the size of the resultant periradicular radiolucency.[14]
In attempting to resolve a periapical lesion of endodontic origin, it is essential to be conscious of these principles in order to effectively combat the infection. Without proper consideration for the causes, the pulpal and periapical infection cannot be suitably treated, for effective patient management requires the correct diagnosis and removal of the cause of the infection of endodontic origin to correct the associated periapical lesion. Because periapical disease is almost inevitably preceded by pulp disease,[1] proper chemomechanical debridement of the infected root canals, together with incision and drainage of associated periradicular swellings, will usually allow for rapid improvement in patient signs and symptoms.[15] The same end can be accomplished by extracting the involved tooth.[7]
Source of infection
Although periapical changes will be in response to pulpal changes the majority of the time, it is still important to determine the disease process sequence. When the disease process is of pulpal origin, the pulpal infection and necrosis may drain not only through the apical foramen, but also through an accessory canal, which may present radiographically as a periradicular or
Focusing on proper procedure
To achieve healing of the periapical lesion, one must obtain and maintain a decontaminated root canal system. System is to be emphasized, because the root canal system does not merely consist of tapering cone-shaped canals from orifice to apex, but rather, can and often is an intricate labyrinth of canals that diverge and weave to form an elaborate web of anastomosing passages.[17] It is precisely because of this reality that “it is important to appreciate that files produce shape, but it is essential to understand that irrigants clean [the] root canal system.[18] Copious amounts of sodium hypochlorite are necessary to utterly dissolve all remnants of pulp tissue as well as completely destroy all microorganisms.[19] The tooth stability does not undergo major changes after surgery comparated with the initial value which was determined before establishing any kind of treatment.[20][21]
Conventional therapy
Many authoritative clinicians and
The traditional thought that it is necessary to complete endodontic therapy as quickly as possible may be related only to the initial steps of therapy, namely, a thorough instrumentation, thus ensuring a proper biomechanical preparation. While completion of the procedure with immediate obturation might secure the decontaminated root canal system, delaying this step in order to allow for application of medicaments has been shown to be beneficial. Periodic application and renewal of calcium hydroxide over a year's time (four applications over a 12-month period), has been shown to represent a nonsurgical approach to resolving even extensive inflammatory periapical lesions.[23]
Antibiotic coverage
The use of adjunctive
Biologic mediators
There are a number of active biologic mediators that have been implicated in promoting apical resorption.
The predominant mechanism of bone resorption in a periapical lesion, as in the rest of the body, is the performed by
Endodontic success and failure
It is possible that after conventional
Non-surgical endodontic retreatment therapy
For retreatment of a non-healing lesion, there is really no magical method that can be employed; the course of action is merely to achieve what was supposed to have been achieved the first time.[30] Keeping in mind the notion that endodontic retreatment is a problem-solving exploit will substantially increase its success.
After endodontic therapy has been executed, or re-executed, successfully, and the canals can no longer provide a nutrient-rich
Situations in which a surgical form of retreatment had been selected and in which apical resolution has still not occurred may still benefit from additional
However, a combination of three antibiotics (metronidazole, ciprofloxacin, and minocycline) in a paste has been used successfully to treat these lesions non-surgically.[34]
References
- ^ a b Lopez-Marcos, JF. Aetiology, classification and pathogenesis of pulp and periapical disease, Med Oral Patol Oral Cir Bucal 2004 9:Suppl pages 58-62, 52-7.
- ^ Nair, PNR: Pathobiology of the Periapex. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 465.
- ^ a b Raven, PH, Johnson, GB. Biology, 5th Edition. Boston: McGraw-Hill Companies, 1999. page 1072.
- ^ Ross, MH, Histology: A Text and Atlas, 3rd Edition. Philadelphia: Lippincott, Williams and Wilkins, 1995. page 339.
- ^ Ross, MH, Histology: A Text and Atlas, 3rd Edition. Philadelphia: Lippincott, Williams and Wilkins, 1995. page 315.
- ^ Lopez-Marcos, JF. Aetiology, classification and pathogenesis of pulp and periapical disease, Med Oral Patol Oral Cir Bucal 2004, 9:Suppl, 58-62, 52-7.
- ^ a b Castellucci, A, Blumenkranz, U: Periapical Disease. In Castellucci, A, editor: Endodontics, Volume 1, Las Vegas: Las Vegas Institute, page 160.
- ^ Fidel, RAS. Complicated crown fracture: a case report, Braz Dent J 2006 17:1 pages 83-86.
- ^ a b Baumgarten, JC, Hutter, JW: Endodontic Microbiology and Treatment of Infections. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 501.
- ^ Blayney, JR: JADA 15:1217-1221, 1928, quoted by Lovdahl, PE, Gutmann, JL: Problems in Nonsurgical Root Canal Retreatment. In Gutmann, JL, editor: Problem Solving in Endodontics, 3rd Edition. St. Louis: Mosby, Inc. 1997, page 157.
- ^ Sgan-Cohen, H.D. Oral hygiene: history and future recommendations. Int J Dent Hyg 2005 3:2 pages 54–58.
- ^ a b Kakehashi, S. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol 1965 Sep 20 pages 340-349.
- ^ Baumgarten, JC, Hutter, JW: Endodontic Microbiology and Treatment of Infections. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 505.
- ^ Baumgarten, JC, Hutter, JW: Endodontic Microbiology and Treatment of Infections. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 503.
- ^ a b c Baumgarten, JC, Hutter, JW: Endodontic Microbiology and Treatment of Infections. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 511.
- ^ Novak, J: Classification of Diseases and Conditions Affecting the Periodontium. In Newman, MG, editor: Carranza’s Clinical Periodontology, 9th Edition. Philadelphia: W.B. Saunders Company, 2002. page 71.
- ^ Gutmann, JL, Witherspoon DE: Obturation of the Cleaned and Shaped Root Canal System. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. pages 296, 332 and 349.
- ^ Ruddle, CJ: Cleaning and Shaping the Root Canal System. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 235.
- ^ Ruddle, CJ: Cleaning and Shaping the Root Canal System. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 258.
- ISSN 2069-3850. 32. Retrieved 2012-06-06.)(webpage has a translation button)
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ISSN 2069-3850. 65. Retrieved 2012-09-12.)(webpage has a translation button)
{{cite journal}}
: CS1 maint: multiple names: authors list (link - ^ Öztan, M.D. Endodontic treatment of teeth associated with a large periapical lesion, Int Endo J Jan 2002 35:1 pages 73-78.
- ^ Soares, J. Nonsurgical treatment of extensive cyst-like periapical lesion of endodontic origin, Int Endo J Jul 2006 39:7 pages 566-575.
- ^ Hajdaragic-Ibricevic, H. The effects of propolis on the reparative processes of the pulp and histological analysis of the pulp 28 days after artificial exposure and covering with propolis, Stomatol Vjesn 1983 12:3-4 pages 111-114.
- ^ da Silva, Fabiane B. Natural medicaments in endodontics - a comparative study of the anti-inflammatory action, Braz Oral Res June 2004 18:2 pages 174-179.
- ^ a b Nair, PNR: Pathobiology of the Periapex. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 470.
- ^ Nair, PNR: Pathobiology of the Periapex. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 468.
- ^ Nair, PNR: Pathobiology of the Periapex. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 482.
- ^ Nair, PNR: Pathobiology of the Periapex. In Cohen, S. Burns, RC, editors: Pathways of the Pulp, 8th Edition. St. Louis: Mosby, Inc. 2002. page 486.
- ^ Lovdahl, PE, Gutmann, JL: Problems in Nonsurgical Root Canal Retreatment. In Gutmann, JL, editor: Problem Solving in Endodontics, 3rd Edition. St. Louis: Mosby, Inc. 1997, page 157.
- ^ Fidel, Rivail A.S., Complicated crown fracture: a case report, Braz Dent J 2006 17:1 pages 83-86.
- ^ Murphy, WK, Healing of periapical radiolucencies after nonsurgical endodontic therapy, Oral Surg Oral Med Oral Pathol 1991 May;71(5):620-4.
- ^ Gagliani, M. Periapical resurgery versus periapical surgery: a 5-year longitudinal comparison. Int Endo J May 2005 38:5 pages 320-327.
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