Julian Downward

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Julian Downward

FMedSci
Born (1960-10-25) 25 October 1960 (age 63)[1]
Employer
Websitehttp://crick.ac.uk/research/a-z-researchers/researchers-d-h/julian-downward/ Edit this on Wikidata
Scientific career
FieldsCancer biology[2]
ThesisThe structure and function of the receptor for epidermal growth factor (1986)
Doctoral advisorMichael Waterfield
Other academic advisorsRobert Weinberg
Websitecrick.ac.uk/research/a-z-researchers/researchers-d-h/julian-downward/

David Julian Harry Downward[

Institute of Cancer Research.[3] He was formerly head of the Signal transduction Laboratory at the London Research Institute.[4][5][6][2]
He is a member of the Editorial Board for Cell.[7]

Education

Downward was educated at

PhD was supervised by Michael Waterfield at the Imperial Cancer Research Fund where he investigated Epidermal growth factor receptor, establishing in 1984 the close similarity between this cellular growth regulatory protein and the avian retroviral oncogene, v-erbB.[8] This work led to the identification of the closely related cellular oncogene ErbB2/HER2, which is over-expressed in a major subset of breast cancers and is the target of the important targeted therapy, trastuzumab.[9] From 1986 to 1989, he was a postdoctoral researcher with Robert Weinberg, at the Whitehead Institute for biomedical research at the Massachusetts Institute of Technology.[10][11]

Research

Downward's research investigates

oncogenic Ras that allows anchorage-independent growth of transformed cells.[3][12]
Most recently he has focused on identifying unique weaknesses of cancer cells expressing the activated Ras oncogene using a combination of large-scale functional genomics and pre-clinical models of lung cancer.

Awards and honours

Downward was elected a

Faculty of 1000 from 2001 to 2005.[13]
He is a member of the European Molecular Biology Organisation (1995) and an honorary Fellow of the Royal College of Physicians (2012).

Personal life

Downward is the son of

Major General Sir Peter Aldcroft Downward, KCVO, CB, DSO, DFC.[1][9][14]
He has three daughters.

References

  1. ^ a b c d "DOWNWARD, Prof. Julian". Who's Who. Vol. 2016 (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
  2. ^ a b Julian Downward publications indexed by Google Scholar
  3. ^ a b c "Dr Julian Downward FMedSci FRS". London: Royal Society. Archived from the original on 19 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  4. Institute of Cancer Research. Archived from the original
    on 7 September 2015.
  5. S2CID 43074411
    .
  6. PMID 21779497
    .
  7. ^ "Editorial board: Cell".
  8. OCLC 940270478
    .
  9. ^
    ISBN 978-1-621820-77-2
    .
  10. ^ "Julian Downward". rnaiglobal.org. Archived from the original on 4 March 2016.
  11. PMID 2901087. Open access icon
  12. YouTube
  13. ^ "Julian Downward". f1000.com
  14. ^ "Major-General Sir Peter Downward - obituary". The Telegraph. Archived from the original on 7 February 2016.
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