Metrizoic acid

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Metrizoic acid
Skeletal formula of metrizoic acid
Space-filling model of the metrizoic acid molecule
Clinical data
ATC code
Identifiers
  • 3-(acetylamino)-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic acid
JSmol)
  • CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)N(C)C(=O)C)I
  • InChI=1S/C12H11I3N2O4/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19/h1-3H3,(H,16,18)(H,20,21)
  • Key:GGGDNPWHMNJRFN-UHFFFAOYSA-N

Metrizoic acid is a

urinary tract), but it has been discontinued, at least in the US.[3]

It was used in form of its salts, metrizoates. Due to its high

osmolality, metrizoic acid had a risk of inducing allergic reactions higher than that of lower osmolar contrast media.[4]

Chemistry

The iodine content of metrizoate ranged from 370 mg/ml to 440 mg/ml, with osmolarity has high as 2100 mOsm/kg. The viscosity is 3.4 cP at 37 degree Celsius (human body temperature).[5]

Adverse effects

Side effects of metrizoate are: urticaria, headache, nausea, vomiting, dizziness, and hypotension. Other side effects include minor electrocardiographic changes such as tachycardia, bradycardia, and inversion of T waves.[6]

References

  1. S2CID 27742637
    .
  2. PMID 6147958
    .
  3. ^ "Metrizoic acid". DrugBank. Retrieved 3 March 2017.
  4. ^ "Metrizoic acid - C12H11I3N2O4". PubChem. U.S. National Library of Medicine. Retrieved 3 March 2017.
  5. ^ Patel R. "Applications in contrast imaging: contrast media basics - important considerations for the pharmacist" (PDF). Braco Diagnostics, Inc. Archived from the original (PDF) on 15 December 2022. Retrieved 15 December 2022.
  6. PMID 4166780
    .
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