Metrizamide
 | |
| Clinical data | |
|---|---|
| Trade names | Amipaque |
| Other names | 3-aAcetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| ATC code | |
| Identifiers | |
| |
ECHA InfoCard | 100.045.872 |
| Chemical and physical data | |
| Formula | C18H22I3N3O8 |
| Molar mass | 789.100 g·mol−1 |
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Metrizamide is a
non-ionic iodine-based radiocontrast agent.[1] It is also a density gradient medium for the centrifugation of biological particles.[2]
Historically metrizamide replaced
X-ray study of the spine now largely replaced by MRI
). The radio opacity characteristics are such that finer detail is displayed with metrizamide, as well as the advantage of reabsorption from spinal fluid and excretion from the body – since unlike iofendylate, metrizamide is a water-soluble substance.
Both agents are administered by
blood brain barrier
, side effects are more likely encountered. Issues related to absorption into the general circulation are also encountered.
Side effects
- Headache
- Nausea
- Vomiting
- herniation, and major central nervous system complications including spinal cord compression
- Seizures
- Muscle rigidity and dystonicreaction
- Aphasia[3]
- Adverse neurobehavioral reactions[4]
History
Metrizamide was approved in the US in 1978. Its marketing is discontinued as of 2021.[5]
References
- PMID 6103672.
- ^ Inaba, Kayo (2011). Current Protocols in Immunology. Isolation of Dendritic Cells: Wiley. p. 3.7.14.
- ^ Kassicieh et al. (1988), Conduction aphasia following metrizamide myelography, J Am Osteopath Assoc 1988 Vol. 88 Issue 3 Pages 384-6
- PMID 6824454.
- ^ "Drugs@FDA: FDA-Approved Drugs: Amipaque". Food and Drug Administration. Retrieved 2021-03-31.
Further reading
- Ozdoba C, Gralla J, Rieke A, Binggeli R, Schroth G (2011). "Myelography in the Age of MRI: Why We Do It, and How We Do It". Radiology Research and Practice. 2011: 329017. PMID 22091378.
- Boyd WR, Gardiner GA (September 1977). "Metrizamide myelography". AJR. American Journal of Roentgenology. 129 (3): 481–4. PMID 409203.
External links
- "Metrizamide". The Free Dictionary.
- "Metrizamide". Drugs.com.