Iotrolan
Clinical data | |
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Trade names | Isovist |
AHFS/Drugs.com | International Drug Names |
Pregnancy category |
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ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | Negligible |
Excretion | 99% via kidneys |
Identifiers | |
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JSmol) | |
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Iotrolan (trade name Isovist) is an
As of 2021[update], it is unknown whether it is still marketed anywhere in the world.
Medical uses
It is particularly used to image spaces surrounding the
Contraindications
Hysterosalpingography is contraindicated during pregnancy and during acute inflammation in the
Adverse effects
The most common side effects are nausea and vomiting. Redness and a hot feeling of the skin is relatively common when the medication is injected into a vein. When injected into the cerebrospinal fluid, headache is among the most common adverse effects, and sometimes confusion or hallucinations can occur. Allergy-like reactions such as fever, hypotension (low blood pressure) and shock have also been observed.[2]
Interactions
Drug interactions are similar to other iodine-containing contrast agents. Iodine-131, a radioactive isotope used for thyroid imaging (scintigraphy) and therapy of thyroid cancers, can be less effective when used within two to six weeks after application of iotrolan because of residual iodine in the body. Iotrolan can slow down the excretion of the diabetes drug metformin, potentially resulting in lactic acidosis.[2]
Chemistry and mechanism of action
Chemically, the substance is a
References
- PMID 8209595.
- ^ a b c d e Haberfeld H, ed. (2020). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Isovist 240 mg J/ml-Stechampulle; Isovist 280 mg J/ml-parenterale Röntgenkontrastmittellösung.
- ^ "Package insert". Archived from the original on 2019-08-25. Retrieved 2011-09-16.