Pedunculopontine nucleus
 |
| Pedunculopontine nucleus | |
|---|---|
| Details | |
| Identifiers | |
| Latin | nucleus tegmentalis pedunculopontinus |
| MeSH | D045042 |
| NeuroNames | 504 |
| NeuroLex ID | birnlex_1437 |
| TA98 | A14.1.06.336 |
| TA2 | 5895 |
| FMA | 72429 |
| Anatomical terms of neuroanatomy | |
The pedunculopontine nucleus (PPN) or pedunculopontine tegmental nucleus (PPT or PPTg) is a collection of neurons located in the upper
Structure and projections
The pedunculopontine nucleus lies below the red nucleus, caudal to the substantia nigra and adjacent to the superior cerebellar peduncle. It has two divisions of subnuclei; the pars compacta, containing mainly cholinergic neurons, and the pars dissipata, containing mainly glutamatergic neurons and some non-cholinergic neurons.[2]
Its
It receives inputs from many areas of the brain.
Functions
The pedunculopontine nucleus is involved in many functions, including
Recent research has discovered that the pedunculopontine nucleus is involved in the planning of movement, and that different networks of neurons in the pedunculopontine nucleus are switched on during real and imagined movement.[11]
Parkinson's disease
Research is being done on whether deep brain stimulation of the pedunculopontine nucleus might be used to improve the gait and postural difficulties found in Parkinson's disease.[3][6]
References
- ISBN 978-0-323-35446-2.
- ^ PMID 29755338.
- ^ PMID 20702790.
- ^ S2CID 40467457.
- ^ S2CID 23034945.
- ^ S2CID 22239596.
- S2CID 14475183.
- ^ Über die Kerne des menschlichen Hirnstamms (Medulla oblongata, Pons und Pedunculus cerebri), Berlin, 1909. pag. 58, fig. 22
- ^ PMID 21503154.
- S2CID 3348936.
- ^ S2CID 405368.
