Phosphoribosyl-N-formylglycineamide
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IUPAC name
(1R)-1,4-Anhydro-1-(N2-formylglycinamido)-D-ribitol 5-(dihydrogen phosphate)
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Systematic IUPAC name
[(2R,3S,4R,5R)-5-(2-Formamidoacetamido)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | |
Other names
Formylglycinamide ribonucleotide,
Formylglycinamide ribotide, FGAR | |
Identifiers | |
3D model (
JSmol ) |
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ChemSpider | |
MeSH | Phosphoribosyl-N-formylglycineamide |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C8H15N2O9P | |
Molar mass | 314.187 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phosphoribosyl-N-formylglycineamide (or FormylGlycinAmideRibotide, FGAR) is a biochemical intermediate in the formation of
FGAR is formed when the enzyme
- GAR + 10-formyltetrahydrofolate → FGAR + tetrahydrofolate
The biosynthesis pathway next converts FGAR to an
5'-phosphoribosylformylglycinamidine (FGAM) in a reaction that also requires ATP:[6]
- FGAR + ATP + glutamine + H2O → FGAM + ADP + glutamate + Pi
See also
References
- ^ R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc Metabolic Pathway Database. Retrieved 2022-02-02.
- S2CID 234897784.
- PMID 20886485.
- ^ R. Caspi (2019-09-23). "Pathway: 5-hydroxybenzimidazole biosynthesis (anaerobic)". MetaCyc Metabolic Pathway Database. Retrieved 2022-02-10.
- PMID 26237670.
- ^ PMID 20631005.