Phosphoribosylamine

Source: Wikipedia, the free encyclopedia.
Phosphoribosylamine
Names
Other names
PRA
Identifiers
3D model (
JSmol
)
ChEBI
ChemSpider
MeSH Phosphoribosylamine
  • InChI=1S/C5H12NO7P/c6-5-4(8)3(7)2(13-5)1-12-14(9,10)11/h2-5,7-8H,1,6H2,(H2,9,10,11)/t2-,3-,4-,5?/m1/s1 checkY
    Key: SKCBPEVYGOQGJN-SOOFDHNKSA-N checkY
  • C([C@@H]1[C@H]([C@H](C(O1)N)O)O)OP(=O)(O)O
Properties
C5H12NO7P
Molar mass 229.125 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Phosphoribosylamine (PRA) is a biochemical intermediate in the formation of

cobalamin[5] also contain fragments derived from PRA.[6]

Phosphoribosyl pyrophosphate (PRPP)

It is the product of the enzyme

anomeric carbon:[2]

PRPP + glutamine → PRA + glutamate + PPi

The biosynthesis pathway next combines PRA with glycine in a process driven by ATP giving glycineamide ribonucleotide (GAR). The enzyme phosphoribosylamine—glycine ligase catalyses the reaction forming an amide bond:[7]

PRA + glycine + ATP → GAR + ADP + Pi

See also

References

  1. ^ R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc Metabolic Pathway Database. Retrieved 2022-02-02.
  2. ^
    PMID 18712276
    .
  3. S2CID 234897784
    .
  4. PMID 20886485
    .
  5. ^ R. Caspi (2019-09-23). "Pathway: 5-hydroxybenzimidazole biosynthesis (anaerobic)". MetaCyc Metabolic Pathway Database. Retrieved 2022-02-10.
  6. PMID 26237670
    .
  7. PMID 20631005
    .
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