Psyllium

Source: Wikipedia, the free encyclopedia.
For the town of ancient Bithynia in Asia Minor, see Psyllium (Bithynia).

Psyllium Husk (Isbagol)
Psyllium husk after processing
Plantago afra, a member of the plant genus from which psyllium can be derived

Psyllium (

food thickener.[1]
Allergy to psyllium is common in workers frequently exposed to the substance.

Use of psyllium in the diet for three weeks or longer may lower

systolic blood pressure.[5]

The plants from which the seeds are extracted tolerate damp and cool climates, and are mainly cultivated in northern India.

Uses

Preparation

Psyllium is produced mainly for its

hydrophilic, meaning that its molecular structure causes it to attract and bind to water.[6][7]

Food

Psyllium has been used as a

thickener in ice cream and other frozen desserts. A 1.5% weight/volume ratio of psyllium mucilage exhibits binding properties that are superior to a 10% weight/volume ratio of starch mucilage.[8] The viscosity of psyllium mucilage dispersions are relatively unaffected between temperatures of 20 and 50 °C (68 and 122 °F), by pH from 2 to 10, and by salt (sodium chloride) concentrations up to 0.15 M.[8]
Psyllium seed husks can also be used to improve texture in
meatballs, and to thicken sauces.[9] Some people use them to manage symptoms of irritable bowel syndrome
.

Human health

Weight loss

Dietary supplements containing psyllium are sold mainly to aid weight loss, although there is little scientific evidence for such effects.[10]

A 2023 review concluded that psyllium supplementation for 12 weeks by people who were overweight or obese produced a minor amount of weight loss, although the studies assessed had only moderate to low evidence quality.[7]

Constipation

Psyllium is mainly used as a viscous, soluble dietary fiber that is not absorbed by the small intestine.[11] The mechanical action of psyllium mucilage is to absorb excess water while stimulating normal bowel elimination.[12] Although its main use has been as a laxative, it is more accurately regarded as a dietary fiber to reduce the symptoms of both constipation and mild diarrhea.[11][12] The laxative properties of psyllium are attributed to the fiber: it absorbs water and subsequently softens the stool.[11][6] It increases flatulence (gas) to some degree.[13] Psyllium reduces straining during defecation by increasing the bulk of stools, thereby facilitating the transit of stools in the colon.[6] When used to treat constipation, psyllium is taken in doses of 3.5–11 grams per day twice daily.[12]

A 2021 review of over-the-counter treatments for constipation concluded that psyllium has modest effect in treating constipation and is generally safe and well-tolerated.[12] Psyllium may be less effective compared to other products, such as polyethylene glycol, lactulose or fruits like prunes.[12] Psyllium is more effective than docusate.[12]

A 2022 review found that psyllium, in doses of 10 grams per day for at least 4 weeks, was more effective than osmotic or stimulant laxatives for increasing the number of bowel movements per week.[6]

High blood cholesterol

In 1998, the U.S. Food and Drug Administration approved a health claim on food labels for dietary psyllium as a

coronary heart disease.[15] The findings were later confirmed in a meta-analysis that incorporated more evidence.[16] To be eligible for the FDA-allowed health claim, one serving of a manufactured food or dietary supplement must contain at least 1.7 g of psyllium as soluble fiber.[14] Whole oats, barley and foods containing beta-glucan soluble fiber were included as eligible sources for the label claim.[14]

Type 2 diabetes

In 2014, the U.S. Food and Drug Administration approved a qualified health claim for psyllium as a possible benefit for people with diabetes, requiring FDA-approved wording on a product label: "Psyllium husk may reduce the risk of type 2 diabetes, although the FDA has concluded that there is very little scientific evidence for this claim."[17] A meta-analysis published after the FDA decision reported that psyllium provided before meals improved fasting blood glucose and glycated hemoglobin, but that the larger effect was seen in people diagnosed with and being treated for type 2 diabetes, and only a modest improvement for people classified as pre-diabetic.[4]

Hypertension

A 2019 meta-analysis found that use of supplemental psyllium for 8 weeks or longer reduced blood pressure by 2 mmHg in people with hypertension.[18]

Lead content

Some psyllium supplements sold in the USA have been found to contain lead,[19] in some cases exceeding levels requiring a warning label by Proposition 65 of the U.S. state of California.[19] In 2013, in California, a legal settlement required the manufacturer of psyllium supplements to pay US$110,000 and agree to place warning labels on products exceeding acceptable lead levels.[20]

Veterinary medicine

Psyllium fiber dietary supplements are used in veterinary medicine to treat

sand impaction in horses to aid in elimination of sand from the horse's colon.[21]

Adverse effects

Fiber generally has few side effects.[22]

Allergy

Psyllium can cause

allergic reactions, including anaphylaxis.[26] Psyllium may act as a potent inhalant allergen capable of eliciting asthma symptoms.[27] Health care professionals at geriatric care hospitals, who are frequently exposed to psyllium in the laxatives administered to people, are commonly IgE sensitized to psyllium (13.8%), and 8.6% have clinical allergy to psyllium.[28] In order to protect sensitized workers, psyllium has an extremely low occupational exposure limit of 150 ng/m3.[29]

Cultivation

The genus Plantago contains over 200 species. P. ovata and P. psyllium are produced commercially in several European countries, Russia and surrounding countries, and India. Plantago seed, known commercially as black, French, or Spanish psyllium, is obtained from P. psyllium, also known as P. arenaria. Seed produced from P. ovata is known in trading circles as white or blonde psyllium, Indian plantago, or isabgol. Isabgol is the common name in India for P. ovata. India dominates the world market in the production and export of psyllium.

Plantago ovata is an annual herb that grows to a height of 30–46 cm (12–18 in). Leaves are opposite, linear or linear

lanceolate
1 cm × 19 cm (0.39 in × 7.48 in). The root system has a well-developed tap root with few fibrous secondary roots. A large number of flowering shoots arise from the base of the plant. Flowers are numerous, small, and white. Plants flower about 60 days after planting. The seeds are enclosed in capsules that open at maturity.

The fields are generally irrigated prior to seeding to achieve ideal soil moisture, to enhance seed soil contact, and to avoid burying the seed too deeply as a result of later irrigations or rainfall. Maximum germination occurs at a seeding depth of 6 mm (1/4 in). Emerging seedlings are frost sensitive; therefore, planting should be delayed until conditions are expected to remain frost free. Seed is broadcast at 5.5 to 8.25 kg/hectare (5 to 7.5 lb/acre) in India. In Arizonan trials, seeding rates of 22 to 27.5 kg/ha (20 to 25 lb/acre) resulted in stands of 1 plant/25mm (1 inch) in 15 cm (6 inch) rows produced excellent yields. Weed control is normally achieved by one or two hand weedings early in the growing season. Control of weeds by pre-plant irrigation that germinates weed seeds followed by shallow tillage may be effective on fields with minimal weed pressure. Psyllium is a poor competitor with most weed species.

Plantago wilt (

White grubs and aphids
are the major insect pests.

The flower spikes turn reddish brown at ripening, the lower leaves dry and the upper leaves yellow. The crop is harvested in the morning after the dew is gone to minimize shattering and field losses. In India, mature plants are cut 15 cm above the ground and then bound, left for a few days to dry, thrashed, and

winnowed
.

Harvested seed must be dried to below 12% moisture to allow for cleaning, milling, and storage. Seed stored for future crops has shown a significant loss in viability after 2 years in storage.

Commercial history

Metamucil

Further information: Metamucil

Introduced in 1934 by

drug-store
distribution as a "behind the counter" product – sold in pharmacies but not on the shelf, so that the pharmacist may counsel the purchaser on correct usage. Since 1974, the brand was also marketed to consumers by print and TV advertising and became available in food outlets. Flavored versions were added in 1979.

The brand is sold as powdered drink mixes, capsules, gummies, and wafers in a variety of flavors. Metamucil contains psyllium seed husks as the active ingredient. It is manufactured in Phoenix, Arizona, by Procter & Gamble.[30] When first marketed to consumers in 1974, Metamucil was marketed as a laxative. The advertising slogan at that time was "If not nature, then Metamucil". Procter & Gamble sought to make Metamucil a household name by advertising in magazines and on television, using the claim "All fiber is not created equal".[31]

References

  1. PMID 23609775
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  2. PMID 25225349
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  3. PMID 30239559
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  4. ^
    PMID 26561625
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  5. PMID 29153856
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  6. ^
    PMID 35816465
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  7. ^
    PMID 37778464
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  8. ^
    PMID 2319
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  9. ^ Priya Krishna (August 17, 2023). "A Centuries-Old Fiber Supplement Entices the Ozempic Generation". The New York Times.
  10. S2CID 81983941
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  11. ^
    PMID 27863994
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  12. ^
    PMID 33767108
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  13. S2CID 34178677
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  14. ^ a b c Sec. 101.81 Health claims: Soluble fiber from certain foods and risk of coronary heart disease (CHD) Archived 2019-05-23 at the Wayback Machine U.S. Food and Drug Administration, Code of Federal Regulations Title 21.
  15. PMID 9311953
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  16. S2CID 205129609
    .
  17. ^ Qualified Health Claim for Diabetes Archived 2017-05-08 at the Wayback Machine US Food and Drug Administration (June 24, 2014).
  18. PMID 32066221
    .
  19. ^ a b "Lead Found In Psyllium Fiber Supplements". February 29, 2024.
  20. ^ "Settlement Agreement and Release" (PDF). State of California - Department of Justice. November 8, 2013.
  21. PMID 30103912
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  22. ^
    PMID 26514720
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  23. ^ "Metamucil oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD". WebMD. Archived from the original on November 18, 2016. Retrieved November 17, 2016.
  24. PMID 8590522
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  25. PMID 29085697
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  26. PMID 14700444
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  27. PMID 11181258
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  28. PMID 18564629
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  29. ^ "Metamucil Orange Coarse Milled Original Texture MSDS" (PDF). Procter & Gamble. Archived (PDF) from the original on July 22, 2019. Retrieved July 22, 2019.
  30. ^ Carilla, Christina (January 25, 2019). "Made In Arizona: Valley factory makes Metamucil for shipping around the world". Fox10. Retrieved January 21, 2020.
  31. ^ Zabin, Jeff (2004). Precision Marketing: The New Rules for Attracting, Retaining, and Leveraging Profitable Customers. John Wiley & Sons. pp. 58–59.
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