Stem cell marker
Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can also be identified by functional assays. Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same.[1] The initial version of the list below was obtained by mining the PubMed database as described in [2]
Stem cell marker names
- AA4[3]
- AA4.1[4]
- P-gp (CD243)[5]
- ABCB5[6]
- ABCG2 (CDw338)[7]
- ALDH[8]
- alkaline phosphatase[9]
- alpha6-integrin[10]
- Anti-WNT2B monoclonal antibody[11]
- antithrombin III (AT)[12]
- asialo GM1[13]
- Bcl-2[14]
- Beta-galactosidase (β-gal) of ROSA26 mice[15]
- beta1-integrin[10]
- bromodeoxyuridine[16]
- c-kit (CD117)[17]
- c-Met[18]
- C1qR(p)[19]
- END (CD105)[20]
- PROM1 (CD133) [21][22][23]
- ALCAM (CD166)[20]
- ITGB1 (CD29)[24]
- TNFRSF8 (CD30)[25]
- PECAM-1 (CD31)[26]
- Siglec-3 (CD33)[27]
- CD34[28]
- CD44[24]
- NCAM (CD56)[29]
- CD73[24]
- CD9[30]
- CD90[31]
- CDCP1[32]
- Circulating anticoagulants protein C (PC)[12]
- CK19[33]
- CLV3[34]
- cyclic CMP[35]
- ECMA-7[36]
- EDR1[37]
- EEC[38]
- FGF-4[39]
- Flk-2[40]
- Flk1(+)[41]
- Flt3/Flk2[42]
- FMS (CD115)[43]
- FORSE-1[16]
- G alpha16[44]
- GDF3[37]
- GFPM[45]
- Giant granules of beige C57B1/6 (bg) mice[46]
- Gli2[47]
- Gli3[47]
- glial fibrillary acidic protein[16]
- glycoprotein IB[48]
- GSTA1[49]
- HAS2 gene expression[50]
- Her5[51]
- hMYADM[52]
- HSA[42]
- hsp25[53]
- Id2[54]
- IL-3Ralpha[55]
- Integrins[56]
- interleukin-3 receptor alpha chain[57]
- Iron oxide nanoparticles[58]
- KDR[59]
- Keratin 15 (aka. CK15, Cytokeratin 15) [33][60][61][62]
- Keratin 19 (aka. CK19, Cytokeratin 19, K19) [63][64][65]
- Kit[4]
- L-selectin (CD62L)[66]
- Lamin A/C[67]
- Lewis X antigen (Le(X))[68]
- LeX[69]
- Lgr5[70]
- Lrp4[71]
- MCM2[72]
- MCSP[73]
- Metallothionein (MT) crypt-restricted immunopositivity indices (MTCRII)[74]
- monosomy 7[75]
- Mouse orthologue of ARX[76]
- MRP4[77]
- Msi-1[78]
- Musashi[78]
- Musashi-1[79]
- Mutant BCRP[80]
- nestin[81]
- neurofilament microtubule-associated protein 2[82]
- neuron-glial antigen 2 (NG2)[83]
- notch 1[84]
- nrp-1[85]
- Nucleostemin[86]
- OC.3[87]
- Oct-4[88]
- OST-PTP[89]
- P-gp/MDR1[90]
- p21[65]
- p63[91]
- p75[92]
- PCLP[93]
- PCNA[16]
- PECAM[7]
- PgP-1[42]
- phosphorylating-p38[94]
- Podocalyxin[95]
- procalcitonin (PCT)[96]
- PSCs[97]
- pSV2gpt[98]
- PTPRC[24]
- purified LRC[99]
- Rat liver fatty acid-binding protein/human growth hormone transgenes (Fabpl/hGH)[100]
- RC1 antigen[101]
- Rex-1[102]
- Sca-1[103]
- SCF[104]
- Sialyl-lactotetra[105]
- Side Population (SP)[106]
- SOX10[92]
- SOX2[107]
- SOX9[108]
- SP phenotype[109]
- SSEA-1[110]
- SSEA-3[111]
- SSEA-4[112]
- Stat3[113]
- Stat5[114]
- Stella[37]
- Stra8[115]
- Stro-1[116]
- Tartrate-resistant acid phosphatase (TRAcP)[117]
- TdT[118]
- telomerase reverse transcriptase[112]
- electrophoretic pattern of hemoglobin[119]
- Thrombomucin[120]
- Thy-1[121]
- Tra-1-60[122]
- TWIST1[123]
- VEGFR-2[124]
- vimentin[125]
- X-Smoothened[47]
- XKrk1[126]
- Zac1[16]
References
- ^ "Appendix E: Stem Cell Markers". Stem Cell Information. Bethesda, Maryland: National Institutes of Health. 17 June 2001. Archived from the original on 13 October 2010. Retrieved 23 July 2009.
- ^ Trifan M, Perez-Iratxeta C, Andrade-Navarro MA, Ionescu D (July 13–16, 2009). "Text Mining and Semantic Search with a Predicate Argument Structure Database". International Conference on Bioinformatics & Computational Biology, BIOCOMP 2009, Las Vegas Nevada, USA, 2 Volumes.
- PMID 10403644.
- ^ PMID 16107475.
- PMID 15950972.
- PMID 15899824.
- ^ S2CID 24731040.
- PMID 16857736.
- S2CID 44838980.
- ^ PMID 10318913.
- PMID 16273293.
- ^ PMID 9052918.
- PMID 6171918.
- PMID 7517223.
- S2CID 84476256.
- ^ PMID 15844099.
- PMID 17290032.
- PMID 15086173.
- PMID 12140365.
- ^ PMID 16827724.
- PMID 10648408. Archived from the originalon 1 August 2012.
- S2CID 34612314.
- PMID 15917475.
- ^ PMID 16945998.
- PMID 10612460.
- PMID 15238461.
- S2CID 23249080.
- PMID 17177848.
- PMID 11391527.
- PMID 12954725.
- PMID 12727209.
- PMID 16926850.
- ^ S2CID 36332628.
- PMID 10761929.
- PMID 6265079.
- PMID 3127777.
- ^ PMID 16168501.
- PMID 3332094.
- PMID 10557354.
- PMID 11724967.
- PMID 15124016.
- ^ PMID 10445502.
- PMID 9207445.
- PMID 10214866.
- S2CID 363563.
- PMID 2857651.
- ^ PMID 12620982.
- S2CID 22696799.
- PMID 9135742.
- PMID 16564133.
- PMID 17038515.
- PMID 17097684.
- PMID 1451960.
- PMID 16481593.
- PMID 14671644.
- PMID 16690778.
- PMID 11021753.
- S2CID 146234.
- PMID 10477517.
- S2CID 24472070.
- S2CID 9143641.
- PMID 16818453.
- PMID 15265523.
- PMID 15740645. Archived from the originalon 2018-06-20.
- ^ PMID 16300651.
- S2CID 14139402.
- PMID 16179429.
- S2CID 25818208.
- PMID 16914687.
- S2CID 4349637.
- PMID 16434236.
- PMID 16556617.
- PMID 14573520.
- PMID 15928667.
- S2CID 13625788.
- S2CID 40260300.
- S2CID 24964880.
- ^ PMID 15617686.
- PMID 16888282.
- PMID 15694832.
- S2CID 22564575.
- S2CID 19612122.
- S2CID 25845185.
- PMID 16297384.
- ]
- S2CID 20104916.
- S2CID 26720468.
- PMID 16344273.
- PMID 11956493.
- PMID 11734301.
- PMID 15604268.
- ^ PMID 17158956.
- PMID 15009070.
- PMID 12970901.
- PMID 15701716.
- PMID 16415895.
- PMID 15277399.
- PMID 11894931.
- PMID 15369213.
- PMID 1634547.
- S2CID 7010999.
- PMID 16793732.
- PMID 12379804.
- PMID 16460677.
- PMID 24841197.
- PMID 15539950.
- PMID 16330757.
- S2CID 43589895.
- S2CID 10879813.
- S2CID 1995302.
- S2CID 40571896.
- ^ PMID 16608390.
- PMID 15616223.
- PMID 9566306.
- PMID 15774719.
- S2CID 31410579.
- PMID 3511985.
- S2CID 21174031.
- PMID 2890388.
- PMID 9298993.
- PMID 16769813.
- PMID 17253942.
- PMID 16510576.
- PMID 16615115.
- S2CID 6076819.
- PMID 7619732.