TGFB1I1
Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene.[5][6] Often put together with and studied alongside TGFB1I1 is the mouse homologue HIC-5 ( Hydrogen Peroxide-Inducible Clone-5). As the name suggests, TGFB1I1 is an induced form of the larger family of TGFB1. Studies suggest TGFB1I1 plays a role in processes of cell growth, proliferation,[7] migration, differentiation[8] and senescence.[9] TGFB1I1 is most localized at focal adhesion complexes of cells,[5] although it may be found active in the cytosol, nucleus and cell membrane as well.[7][10][11]
Functions
Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide.[9] During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein,[12][13] an androgen and glucocorticoid receptor co-activator,[10][14] a negative regulator of muscle differentiation,[8] and major player in the recovery of arterial media.[15][16]
Interactions
TGFB1I1 has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000140682 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030782 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 9422762.
- PMID 10075738.
- ^ PMID 16849583.
- ^ PMID 10468589.
- ^ PMID 7929412.
- ^ PMID 10848625.
- PMID 12631731.
- PMID 10092676.
- PMID 9858471.
- PMID 10075738.
- PMID 25433074.
- PMID 22472216.
- ^ PMID 11856738.
- PMID 11779876.
- PMID 12177201.
- PMID 11546764.
- ^ PMID 9858471.
- PMID 11463817.
- PMID 10092676.
Further reading
- Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, et al. (December 2000). "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer". Journal of the Formosan Medical Association = Taiwan Yi Zhi. 99 (12): 885–894. PMID 11155740.
- Heitzer MD, DeFranco DB (February 2007). "Hic-5/ARA55: a prostate stroma-specific AR coactivator". Steroids. 72 (2): 218–220. S2CID 38796305.
- Wilson SE, Lloyd SA (September 1991). "Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells". Investigative Ophthalmology & Visual Science. 32 (10): 2747–2756. PMID 1716619.
- Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence". The Journal of Biological Chemistry. 269 (43): 26767–26774. PMID 7929412.
- Shibanuma M, Mochizuki E, Maniwa R, Mashimo J, Nishiya N, Imai S, et al. (March 1997). "Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts". Molecular and Cellular Biology. 17 (3): 1224–1235. PMID 9032249.
- Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K (October 1998). "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase". The Journal of Biological Chemistry. 273 (41): 26516–26521. PMID 9756887.
- Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 ( Pt 2) (2): 181–190. PMID 9858471.
- Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–9853. PMID 10092676.
- Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, et al. (May 1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling". The Journal of Cell Biology. 145 (4): 851–863. PMID 10330411.
- Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH (December 1999). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–681. S2CID 2770368.
- Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix". Molecular Biology of the Cell. 11 (6): 2007–2018. PMID 10848625.
- Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, et al. (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–2639. PMID 11313252.
- Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–5345. PMID 11463817.
- Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". The Journal of Biological Chemistry. 276 (43): 39911–39918. PMID 11546764.
- Ting HJ, Yeh S, Nishimura K, Chang C (January 2002). "Supervillin associates with androgen receptor and modulates its transcriptional activity". Proceedings of the National Academy of Sciences of the United States of America. 99 (2): 661–666. PMID 11792840.
- Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, et al. (April 2002). "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5". The Journal of Biological Chemistry. 277 (14): 12270–12274. PMID 11805099.
- Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". The Journal of Biological Chemistry. 277 (18): 15426–15431. PMID 11856738.
External links
- TGFB1I1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C148
This article incorporates text from the United States National Library of Medicine, which is in the public domain.