Nuclear receptor co-repressor 2
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| Location (UCSC) | Chr 12: 124.32 – 124.57 Mb | Chr 5: 125.02 – 125.18 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[5][6] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[5] or T3 receptor-associating cofactor 1 (TRAC-1).[6]
Function
NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three
corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[7]
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.[8]
Discovery
SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[5] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[6]
Interactions
Nuclear receptor co-repressor 2 has been shown to
interact
with:
- AR,[9][10][11]
- BCL6,[12][13][14]
- C-Fos,[15]
- C-jun,[15]
- HDAC1,[16][17]
- HDAC3,[17][18][19][20][21][22][23]
- HDAC4,[22][24]
- HDAC5,[24]
- HDAC10,[16]
- MeCP2,[25]
- NR4A1,[26]
- POU2F1,[27]
- PPARD,[28]
- PGR,[29]
- PML[30][31]
- RBPJ,[32][33]
- RELA,[15][34]
- RUNX1T1,[35][36]
- RARA,[37][38]
- SIN3A,[18][24]
- SNW1,[39][40]
- SPEN,[41]
- SRF,[15]
- TBL1X,[18][19][20][21]
- THRB,[42][43][44]
- and
- ZBTB16.[12][35][38]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196498 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029478 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 4361329.
- ^ PMID 8813722.
- S2CID 14686941.
- ^ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
- PMID 12441355.
- PMID 14593076.
- PMID 11923464.
- ^ PMID 9765306.
- PMID 10898795.
- PMID 10611298.
- ^ PMID 10777532.
- ^ PMID 11739383.
- ^ PMID 11013263.
- ^ PMID 10944117.
- ^ PMID 12628926.
- ^ PMID 12502735.
- ^ PMID 10809664.
- ^ PMID 11804585.
- PMID 14527417.
- ^ PMID 10640275.
- PMID 23770565.
- PMID 11559707.
- PMID 11134019.
- PMID 11867749.
- PMID 10757795.
- PMID 11430826.
- PMID 11585900.
- S2CID 9526831.
- PMID 11509665.
- PMID 12589049.
- ^ PMID 14982881.
- PMID 11113190.
- PMID 11929748.
- ^ PMID 9256429.
- PMID 10644367.
- PMID 10713164.
- PMID 11331609.
- PMID 9751500.
- ^ PMID 9878542.
- PMID 11518802.
- PMID 12460926.
Further reading
- Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK (October 1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature. 377 (6548): 397–404. S2CID 4230850.
- Chen JD, Evans RM (October 1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. S2CID 4361329.
- Sande S, Privalsky ML (July 1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Molecular Endocrinology. 10 (7): 813–25. PMID 8813722.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (July 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. S2CID 25999127.
- Hong SH, David G, Wong CW, Dejean A, Privalsky ML (August 1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9028–33. PMID 9256429.
- Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (August 1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell. 90 (3): 569–80. S2CID 15284825.
- Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. S2CID 4383951.
- Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (July 1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Molecular Cell. 2 (1): 33–42. PMID 9702189.
- Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. PMID 9751500.
- Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry. 273 (42): 27695–702. PMID 9765306.
- Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM (March 1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT". Proceedings of the National Academy of Sciences of the United States of America. 96 (6): 2639–44. PMID 10077563.
- Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD (March 1999). "SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3519–24. PMID 10097068.
- Nguyen TA, Hoivik D, Lee JE, Safe S (July 1999). "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex". Archives of Biochemistry and Biophysics. 367 (2): 250–7. PMID 10395741.
- Bailey P, Downes M, Lau P, Harris J, Chen SL, Hamamori Y, Sartorelli V, Muscat GE (July 1999). "The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD". Molecular Endocrinology. 13 (7): 1155–68. PMID 10406466.
- Kao HY, Downes M, Ordentlich P, Evans RM (January 2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes & Development. 14 (1): 55–66. PMID 10640276.
- Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. PMID 10713164.
- Lee SK, Kim JH, Lee YC, Cheong J, Lee JW (April 2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". The Journal of Biological Chemistry. 275 (17): 12470–4. PMID 10777532.
- Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes & Development. 14 (9): 1048–57. PMID 10809664.
- Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proceedings of the National Academy of Sciences of the United States of America. 97 (14): 7835–40. PMID 10869435.
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External links
- nuclear receptor corepressor 2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C98