TRIM24
Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.[5][6][7]
Function
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the
vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains – a RING, a B-box type 1 and a B-box type 2 – and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]
Interactions
TRIM24 has been shown to
interact with Mineralocorticoid receptor,[6][8] TRIM33,[9] Estrogen receptor alpha[6][10] and Retinoid X receptor alpha.[6][11]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000122779 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029833 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: TRIM24 tripartite motif-containing 24".
- ^ PMID 9115274. Archived from the originalon 2005-01-24. Retrieved 2009-02-22.
- PMID 9191165.
- PMID 11518808.
- PMID 12096914.
- S2CID 23486519.
- PMID 11851396.
Further reading
- Le Douarin B, Nielsen AL, You J, et al. (1997). "TIF1 alpha: a chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors?". Biochem. Soc. Trans. 25 (2): 605–12. PMID 9191165.
- Moosmann P, Georgiev O, Le Douarin B, et al. (1997). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. 24 (24): 4859–67. PMID 9016654.
- Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". J. Biol. Chem. 272 (18): 12062–8. PMID 9115274.
- Fraser RA, Heard DJ, Adam S, et al. (1998). "The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors". J. Biol. Chem. 273 (26): 16199–204. PMID 9632676.
- Eng FC, Barsalou A, Akutsu N, et al. (1998). "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain". J. Biol. Chem. 273 (43): 28371–7. PMID 9774463.
- Venturini L, You J, Stadler M, et al. (1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. PMID 10022127.
- Remboutsika E, Lutz Y, Gansmuller A, et al. (1999). "The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin". J. Cell Sci. 112 (11): 1671–83. PMID 10318760.
- Klugbauer S, Rabes HM (1999). "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene. 18 (30): 4388–93. S2CID 2166439.
- Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. PMID 10562550.
- Thénot S, Bonnet S, Boulahtouf A, et al. (2000). "Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors". Mol. Endocrinol. 13 (12): 2137–50. S2CID 23486519.
- Zhong S, Delva L, Rachez C, et al. (1999). "A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins". Nat. Genet. 23 (3): 287–95. S2CID 23613492.
- Hellal-Levy C, Fagart J, Souque A, et al. (2001). "Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor". Mol. Endocrinol. 14 (8): 1210–21. PMID 10935545.
- Seeler JS, Marchio A, Losson R, et al. (2001). "Common Properties of Nuclear Body Protein SP100 and TIF1α Chromatin Factor: Role of SUMO Modification". Mol. Cell. Biol. 21 (10): 3314–24. PMID 11313457.
- Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. PMID 11331580.
- Zennaro MC, Souque A, Viengchareun S, et al. (2002). "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action". Mol. Endocrinol. 15 (9): 1586–98. PMID 11518808.
- Lee WY, Noy N (2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry. 41 (8): 2500–8. PMID 11851396.
- Gandini D, De Angeli C, Aguiari G, et al. (2002). "Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML". Leukemia. 16 (5): 886–93. PMID 11986951.
- Peng H, Feldman I, Rauscher FJ (2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. 320 (3): 629–44. PMID 12096914.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
External links
- TRIM24 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C150
This article incorporates text from the United States National Library of Medicine, which is in the public domain.