Talk:SARS-CoV-2/Archive 5

This was hard for me to look at quickly because the references do not display in a way that is very easy to review. Now that it was added to the article, I have seen that some of the sources are copies of things already used. I integrated the text into the first paragraph of the reservoir section. My guess is that the only objection will remain the discussion of how much to discuss wet markets. However, this article is about this virus, and the section is about where the virus came from. Since this article is not about the general effects of wet markets, I reduced that portion of the addition substantially. Please let me know if you have any questions or concerns. Dekimasuよ! 13:21, 26 March 2020 (UTC)

This Severe acute respiratory syndrome coronavirus 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request.

I would like to have the phrase "and most journalists" removed from the sentence "The general public often call both the virus and the disease "coronavirus", but scientists and most journalists typically use more precise terms."

The changed sentence would read ""The general public often call both the virus and the disease "coronavirus", but scientists typically use more precise terms."

Why? 1. The phrase is based on the presumption that all journalists aspire to certain standards and work to meet them. I consider that unlikely because the definition of journalist varies greatly, and most readers, including myself, have seen multiple incorrect statements made by journalists. 2. The difference between a virus and a disease is not the domain of journalism. These are scientific (and medical?) words. (Note: If journalists do, in fact, communicate to the public that there is a difference in the terms, well and good. But, whether they do or not, the difference still exists.) OKRickety (talk) 14:46, 28 March 2020 (UTC)

I would have to agree the logic of that argument. As a minimum, 'most' should go since that implies a measurement that hasn't been made AFIK. I suggest too that these are hand-waving noise words: the distinction between usages is clearer if they are omitted. --

talk

) 15:35, 28 March 2020 (UTC)

"We now know that asymptomatic transmission likely [plays] an important role in spreading this virus," said Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota. Osterholm added that it's "absolutely clear" that asymptomatic infection "surely can fuel a pandemic like this in a way that's going to make it very difficult to control." In an article two weeks ago in the New England Journal of Medicine, Bill Gates, co-chair of the Bill and Melinda Gates Foundation, expressed concern about the spread of the disease by people who haven't yet developed symptoms, or who are only a bit sick. "There is also strong evidence that it can be transmitted by people who are just mildly ill or even presymptomatic. That means COVID-19 will be much harder to contain than the Middle East respiratory syndrome or severe acute respiratory syndrome (SARS), which were spread much less efficiently and only by symptomatic people," he wrote, using the scientific word for the disease caused by the virus. 'Prolonged, unprotected contact' led to first known person-to-person coronavirus transmission in US, study says Others agree that people without serious symptoms play a substantial role in the spread of the new coronavirus. "Asymptomatic and mildly symptomatic transmission are a major factor in transmission for Covid-19," said Dr. William Schaffner, a professor at Vanderbilt University School of Medicine and longtime adviser to the CDC. "They're going to be the drivers of spread in the community." Osterholm urged public officials to be clearer about the way the virus is spread.

Source: https://us.cnn.com/2020/03/14/health/coronavirus-asymptomatic-spread/index.html 73.195.225.148 (talk) 03:51, 15 March 2020 (UTC)

"the best-fitting model has a reporting delay of 9 days from initial infectiousness to confirmation; in contrast line-list data for the same 10–23 January period indicates an average 6.6 day delay from initial manifestation of symptoms to confirmation (17). This discrepancy suggests pre-symptomatic shedding may be typical among documented infections." Source: https://science.sciencemag.org/content/early/2020/03/13/science.abb3221 Pablo Mayrgundter (talk) 18:42, 16 March 2020 (UTC)

My main qualm with overemphasis on the Science study is that the WHO guidance (and guidance from a large range of other organizations to this point) is based upon direct observation, while the study is a mathematical model. There are other variables that could create the same results, up to and including the presence of a considerable number of symptomatic people who didn't seek or receive medical attention. The study does not distinguish between asymptomatic and mild cases of infection; in fact it simply calls the cases "undocumented" rather than "asymptomatic". When it writes that the "high proportion of undocumented infections, many of whom were likely not severely symptomatic" were involved, it is specifically not making such a claim. Dekimasuよ! 10:50, 21 March 2020 (UTC)

"Coronavirus patients with mild symptoms are most infectious within a week of contracting the disease but are unlikely to pass the virus on after 10 days, German researchers have revealed. In the study of just nine patients - one of the first to map when people actively transmit the illness to others - scientists found that patients with mild symptoms emit extremely high amounts of the virus at an early stage of their infection. “Peak shedding” - when a person with Covid-19 is most infectious - typically occurs within five days of picking up the disease, and patients emit 1,000 times more virus than during peak shedding of a Sars (severe acute respiratory syndrome) infection. This very high rate helps to explain why the virus has spread so rapidly across the globe." Source: https://www.telegraph.co.uk/global-health/climate-and-people/patients-mild-coronavirus-symptoms-may-highly-infectious-study/ Original scientific paper: https://www.medrxiv.org/content/10.1101/2020.03.05.20030502v1. Seems to be some debate and this paper is not yet peer-reviewed so treat with caution, but very important if correct. — Preceding unsigned comment added by 90.209.69.100 (talk • contribs)

"Presymptomatic", "asymptomatic", and "exhibiting mild symptoms" are not synonymous, so we have to be even more careful with this. No one has ever implied that people with mild symptoms are incapable of infecting others. Dekimasuよ! 15:35, 17 March 2020 (UTC)

Also note the Italian study in Vo 'Euganeo (report: https://www.repubblica.it/salute/medicina-e-ricerca/2020/03/16/news/coronavirus_studio_il_50-75_dei_casi_a_vo_sono_asintomatici_e_molto_contagiosi-251474302 translated: https://translate.google.com/translate?hl=&sl=auto&tl=en&u=https%3A%2F%2Fwww.repubblica.it%2Fsalute%2Fmedicina-e-ricerca%2F2020%2F03%2F16%2Fnews%2Fcoronavirus_studio_il_50-75_dei_casi_a_vo_sono_asintomatici_e_molto_contagiosi-251474302%2F), and now being written about in UK press: http://www.theguardian.com/commentisfree/2020/mar/20/eradicated-coronavirus-mass-testing-covid-19-italy-vo. 50–75% of case asymptomatic, and consequent huge underestimates in the absence of mass testing; furthermore: infected, asymptomatic key workers are a significant vector for transmission, so likely need to caveat/challenge '(WHO) indicated that "transmission from asymptomatic cases is likely not a major driver of transmission"' — Preceding unsigned comment added by 2A02:1810:290E:AB00:C1BC:6653:88F6:3D5A (talk) 14:21, 20 March 2020 (UTC)

Hello, yesterday night I added information about the natural origin of the virus, based on a recent research publication, but shortly afterwards Dekimasu removed this. I would like to explain the reason for my edit.

1. In this version of the SARS virus article, I read a sentence about the origin of SARS-CoV 2, but it did of course not belong there, so I decided to transfer this to this place.
2. I discovered this article already said, "the strain is known to have a natural origin", but I thought expansion would be helpful, so I did not bluntly copy the text from the other article, but merge both texts.
3. I realized that the source of the transferred text was a summary (in a press release) of the scientific article already mentioned here as a source, but I thought the summary might be more understandable for many readers, so adding this link would still be useful. In other words, I supposed that footnotes can serve as a service for readers desiring more information, but it appears that they are seen as source references here only. (Interestingly, Dekimasu used the same press release source in an earlier edit.) The Wikipedia guideline mentions the possibility of adding a 'lay summary' parameter to the main reference, however, so perhaps I should try that.
4. I thought the finding that the virus has a natural origin is important enough to tell this in a separate sentence, not in a half sentence. Therefore: "The origin is almost certainly natural, not artificial as some rumours held." Mentioning the rumours and discarding them with italics seemed important to me to make very clear those rumours are not true. With the words "almost certainly" I thought I was going in fact a little further than the authors of the Nature article, which used the word "improbable" (but who were more definite in their lead section, saying "Our analyses clearly show ..." there) and gave several reasons to see "Selection during passage" (in cell culture or animal passage) as "unlikely". They concluded "it is currently impossible to prove or disprove the other theories of its origin [including inadvertent laboratory release] described here" but "we do not believe that any type of laboratory-based scenario is plausible".
   (Of course, conspiracy theories about the virus also lack any credibility because there would be no rationale for such actions, even the most despisable government would not do such a thing because the danger it would form to the government itself. But inadvertent lab releases did happen in the past. Perhaps it comes down to the interpretation of the word 'articial'.)

Bever (talk) 01:42, 20 March 2020 (UTC)

Hopefully I can clear this up. First, the same information was added to this article twice in the same day yesterday–because the same editor added the same text both to this article and at the place you found it. When it was added here I changed its location in the article, integrated it into the existing text, then removed the press release 3 minutes later (I did not use the source myself; I removed it as soon as I noticed what it was). The second time, it had already been integrated, so I mostly undid your edit–that is, I treated it as already merged, not a new merge. The source itself was already incorporated into the article, because it had been up on Virological for weeks and we had been using it as a source here. Press releases do not satisfy

WP:MEDRS

and tend toward the promotional.

In my explanation of removing the "rumors" wording, I noted

conspiracy theories in the article such as rumors that the virus was constructed. No reputable scientific sources I am aware of have ever claimed the virus was constructed, with the exception of a single retracted preprint

. This has been discussed previously in the talk page archives and insertion of such rumors was suggested (not by me) as an indication that the article might require extended confirmed protection.

Primarily, unnecessary emphasis on the basically undisputed natural origin of the virus serves to magnify any claims that it is not. For example, we would not add "Contrary to rumor, Queen Elizabeth is not a lizard person" to her article even though there is such a conspiracy theory. To be honest, I think removing the sentence on natural origins would still be the best option, because without such a sentence the origin would be assumed to be natural, particularly given that we state in the lede it was a zoonosis and we have an extended section on the topic at "Reservoir". Dekimasuよ! 02:56, 20 March 2020 (UTC)

You got me – I never realised that Queen Elizabeth could be a lizard person before you wrote about it. ;-) So after a second thought, I agree with your removal of the assertion that the virus is not artificial and the reference to rumours. Also I did not realize that the word "articial" was less suitable for (natural) "adaptation to passage in cell culture", deemed in the Nature article as very unlikely (implausible) but not impossible.

I also understand that you even removed "The origin is natural". As the statement about zoonosis and most of the Reservoir section only tell something about the origin and not about the transmission from its origin to humans, I do however suggest to expand the phrase "when the strain became pathogenic remains unclear" a bit, with the explanation that the virus became either virulent when it was still in another animal or it adapted after the first transmission to a human. Implicitly that would tell the readers about the available natural origin without using the word. Bever (talk) 02:40, 29 March 2020 (UTC)

More POV edits. Disregard this proposed edit. Jtbobwaysf (talk) 12:09, 24 March 2020 (UTC)

I suppose you mean this edit. That was not by me – which one could think after your remark – but by Drbogdan, who possibly did not see this discussion.

Also I do not think it is fair to describe the statement "On 17 March 2020, scientists reported that the novel SARS-CoV-2 virus originated naturally, and not otherwise" as "POV". Dekimasu above calls it unnecessary and it could have the opposite effect from what was meant by it, but it is still reflecting scientific consensus, that is not the problem. Bever (talk) 03:06, 29 March 2020 (UTC)

Various sources say coronavirus has helical capsid. But in any diagram I could not find a capsid beneath the envelop. Can anybody upload a diagram showing which is/ are the helical capsid? Regards RIT RAJARSHI (talk) 15:17, 24 March 2020 (UTC)

It is the inner nucleocapsid that is helical not the outer capsid.Graham Beards (talk) 14:00, 26 March 2020 (UTC)

The article never mentions that the virus has a lipid membrane, which makes all the difference when deciding how decontamination should be carried out. See: https://www.oie.int/en/scientific-expertise/specific-information-and-recommendations/questions-and-answers-on-2019novel-coronavirus/ --46.11.163.38 (talk) 13:30, 26 March 2020 (UTC)

It links viral envelope, which to my knowledge effectively assumes there is a lipid bilayer, although we have not linked Lipid bilayer separately. Dekimasuよ! 13:49, 26 March 2020 (UTC)

I added a wikilink to Lipid bilayer in the Infection section where deactivation by soap is mentioned. Dekimasuよ! 01:26, 27 March 2020 (UTC)

This Severe acute respiratory syndrome coronavirus 2 has been answered. Set the |answered= or |ans= parameter to no to reactivate your request.

Terminology

The SARS-CoV-2 virus strain was previously known by the provisional name 2019 novel coronavirus (2019-nCoV).[12][13][14] The strain was first discovered in Wuhan, China, so it is sometimes referred to as the "Wuhan virus"[15] or "Wuhan coronavirus".[16][17][18][19] Because the World Health Organization discourages the use of names based upon locations,[10][20][21] it sometimes refers to the virus as "the virus responsible for COVID-19" or "the COVID-19 virus" in public health communications.[23] The general public often call both the virus and the disease "coronavirus", but scientists typically use more precise terms.[24]

The term SARS-COV-2 was officially named on February 11, 2020 by the International Committee of Taxonomy of Viruses (ICTV). This is name of the of the virus that is responsible for the Corona Virus Disease of 2019 (COVID-19). The World Health Organization (WHO) officially named it COVID-19 to help differentiate between the original SARS virus (SARS-COV) and the novel virus SARS-COV-2. It is important to note these virus strains are similar but different.

^[1] Gng4life (talk) 09:49, 29 March 2020 (UTC)

Thanks, but this is not why the WHO named it how it did, and the cite does not state it that way. Though it's not clear from the source you're citing, WHO announced its name for the disease before ICTV made its announcement about the relationship to SARS. It is true that the new name was presented on February 11, but it's not clear that this is necessary to state in the article, and the subsection you are referring to doesn't exist at the moment. Dekimasuよ! 04:14, 30 March 2020 (UTC)

I'm just doing my last check before going to sleep over some covid-19 related wikis and I notice this one is suffering severe vandalism. To anyone with the powers to to so, please protect/semi-protect this page. Good night. Feelthhis (talk) 02:36, 3 April 2020 (UTC)

Request pending at Wikipedia:Requests for page protection#Severe acute respiratory syndrome coronavirus 2. Rotideypoc41352 (talk · contribs) 02:50, 3 April 2020 (UTC)

I put in the request immediately; it's pretty cut-and-dried, but I still shouldn't do it myself since I'm clearly involved. Dekimasuよ! 02:55, 3 April 2020 (UTC)

The Polish Minister of Health Szumowski did an interview of which a text version claims that he said Zwykle mówimy o sezonowości występowania wirusa, ale z tym wirusem mamy pierwszy raz do czynienia. Badania laboratoryjne wskazują, że przy 20 stopniach C. przestaje być aktywny. - roughly: We ordinarily talk about the seasonality of [a/the] virus, but with this virus, it's the first time. Laboratory research shows that at 20 deg C [it] stops being active.

Can anyone find some

Boud, there is a recent article that notes of specific enzymes, "Like all proteins, SARS-CoV 3CLpro undergoes thermal denaturation at elevated temperatures, hence the increases in the catalytic efficiency of the protease with increasing temperature might be compromised by the competing effects of the enzyme denaturation at high temperature." There is also a graph here related to the spike protein and luciferase at high temperatures (body temp and higher). I don't see anything about 20C or the overall activity of the virus in normal environmental conditions. Dekimasuよ! 20:46, 2 April 2020 (UTC)

@Dekimasu: Thanks: more likely it was an off-the-cuff remark rather than a serious claim. I think that what would be needed would be the equivalent of what right now is ref [30] = https://doi.org/10.1056%2FNEJMc2004973, repeated for different temperatures/humidities/pressures covering a fair range of surface temperatures of typical living conditions from around the world, to answer the question in a wide sense; or more specifically just trying e.g. from 5 deg C to 45 deg C might be enough to test the hypothesis that "warm/hot/extremely-hot weather kills off SARS-CoV-2". Boud (talk) 21:14, 2 April 2020 (UTC)

This virus will have levels of tolerance to environmental factors such as ultraviolet light, temperature, and humidity. Beyond those levels, when exposed for a period of time, the virus will be destroyed. It would be great to have a section in this article that covers what is currently known about the survivability of this virus. FreeFlow99 (talk) 09:11, 31 March 2020 (UTC)

This information is in the Infection section. I am not aware of any specific research on humidity, etc. Dekimasuよ! 09:45, 31 March 2020 (UTC)

The article does not list the molecular mass of the fully assembled virus. I mentions it size but not the mass. It is an egregious omission. — Preceding unsigned comment added by 83.24.160.89 (talk) 14:05, 31 March 2020 (UTC)

If there is a source that says something about this, feel free to let us know. If no one has published the information in their research, then it's probably an indication that others don't find the omission egregious. Dekimasuよ! 01:40, 2 April 2020 (UTC)

Please clarify use of ACE2 in second paragraph of

Done ACE2 is the receptor. The papers are not talking about a receptor of ACE2. Thank you so much for pointing that out! Rotideypoc41352 (talk · contribs) 17:43, 6 April 2020 (UTC)

The article should mention the recent findings that support the existence of at least two strains of SARS-CoV-2, termed the "L" and "S" strains. Here is the academic article that discovered the divergence: Tang, Xiaolu; Wu, Changcheng; Li, Xiang; Song, Yuhe; Yao, Xinmin; Wu, Xinkai; Duan, Yuange; Zhang, Hong; Wang, Yirong; Qian, Zhaohui; Cui, Jie; Lu, Jian. "On the origin and continuing evolution of SARS-CoV-2". National Science Review.

• Guzman, Joseph (4 March 2020). "The coronavirus could be mutating as scientists claim to have identified a more aggressive strain". TheHill.
• "Coronavirus is mutating. Chinese scientists find second strain". Fortune.

Thanks. 131.128.73.81 (talk) 15:22, 5 March 2020 (UTC)

We will have to keep an eye on this one. The claim is out there, yes. However, the "strain" terminology used here is very imprecise/incorrect (SARS-CoV-2 itself is a single strain according to a normal definition), and there has already been quite a bit of criticism of this paper. As you can see from the article, Nextstrain shows a large number of genomes with small differences. This paper seems to be stating that there is a difference in transmissibility on the basis of one small change, but given that there is a good deal of skepticism about this, I think it is best that we wait for actual

WP:MEDRS-compliant sources rather than relying upon generalist news sources that may be misinterpreting the results. There may be some arbitrariness in their definitions. My guess is that this will not pan out, but I will stay up to date on it. Dekimasuよ!

15:33, 5 March 2020 (UTC)

Example criticism. Dekimasuよ! 15:46, 5 March 2020 (UTC)

The criticism isn't about the existence of the S and L types, but their interpretation. I think however we should wait and see if other people agree with their findings. Hzh (talk) 13:57, 7 March 2020 (UTC)

Well, the study authors are the ones who made up the terms "S" and "L". As you say, the reactions are that it is fairly clear that there are multiple lineages, and some are older than others. But this is always true no matter what lineages are in question, in any organism. What the authors are speculating is that the "S" and "L" lineages represent different transmission and "aggressiveness" patterns–that is, they are claiming that one strain is being selected for, and that this indicates that it is less virulent (though they are not using that term). This could be true, or the pattern could be part of random chance. For instance, we wouldn't speculate that people named "Jones" had different characteristics from people named "Smith" because "Smith" has come to be a more common name.

However, this isn't so much the place to be debating the findings among ourselves. As you said, the main question is whether other reliable sources agree with, disagree with, or ignore this study. Dekimasuよ! 14:10, 7 March 2020 (UTC)

I agree in principle with what has been said already about waiting for a reliable source. Unfortunately there is a fake news item {ok, probably many fake news items] circulating on social media about a "new deadly strain". Do we have any responsibility to counteract this sort of silliness? --

talk

) 14:12, 7 March 2020 (UTC)

This is a fair point too. In many cases I agree that we do have such a responsibility. But I still think in this case the best option for the time being is to wait for sources to make the important points (either for or against the study) for us. Here, the original study argues that the "new deadly strain" basically went away by mid-January, so if the study does make it into the article, it should not be difficult to counteract that part of the rumor. However, there's only so much that can be done on that front; disputing the claim here is just as likely to be fodder for the rumor mill. I am still unsure where this would even be added to the article. Under taxonomy, even though their argument is not taxonomically sound? Under epidemiology, near the basic reproduction number discussion, even though it's unclear what they actually meant by "aggressive"? I suppose subsuming the S/L discussion into the sentence on basic reproduction number estimates would be possible, but that's close to

WP:SYNTH. Dekimasuよ!

15:41, 7 March 2020 (UTC)

Virological has a thread up on this paper in which a team from the University of Glasgow Centre for Virus Research suggest retraction, with an actual analysis similar to some of the points given above. They conclude, "Given these flaws, we believe that Tang et al. should retract their paper, as the claims made in it are clearly unfounded and risk spreading dangerous misinformation at a crucial time in the outbreak." (Still not MEDRS.) In the same way we avoided the Indian HIV paper and (to a large extent) the snakes paper, I think this shows it's good that we have avoided this so far. Apparently the authors of the Chinese study are going to engage with the criticism in follow-ups at National Science Review, so hopefully this will become clearer soon and it will also become more evident whether we really need a debunking sentence in the article. Dekimasuよ! 03:15, 8 March 2020 (UTC)

Similar thread from Trevor Bedford (

Fred Hutchinson Cancer Research Center/University of Washington) with similar criticisms where he writes, "Please consider this thread to be a public peer review of this work." Again, not MEDRS, but helpful for our decision-making process. Excerpt: "Generally, the expectation among virologists is that a random single amino acid change will have little impact on virus behavior. My 'null' model would be that this mutation just happened to occur on an early branch on the tree and any 'impact' is due solely to epidemiology.... Any differences in apparent severity between these two genetic variants are most likely due to sampling of market-associated severe cases in Wuhan and missing the bulk of mild cases in this setting.... In summary, I don't think the strong conclusions of the manuscript are warranted. We will monitor these two genetic variants, but I see no reason to conclude they have important functional significance at this point." Dekimasuよ!

06:01, 9 March 2020 (UTC)

8 strains, as per Nextstrain.com via New York Post and USA Today. TGCP (talk) 21:13, 29 March 2020 (UTC)

There are up to 11 mutations, but these do not actually constitute strains. There is only very little indication that they are functionally different. Newspapers might call them strains, but Nextstrain does not and would not. Evidence of genetic diversity is not the same thing as having "8 strains". If medical/scientific sources use that sort of language, we can of course revisit this, but the article itself is already on a single strain of the overarching virus species, as noted above. Dekimasuよ! 14:04, 30 March 2020 (UTC)

Hello! Professors from the University of the Basque Country have made public this diagram of the life cycle of SARS-CoV2 virus. Yesterday I added to the article, because it is a high quality image, but @Dekimasu: deleted it. I would like to have another opinion about this, because I think this image is really interesting and well done. -Theklan (talk) 09:10, 28 March 2020 (UTC)

I wrote: "this is great, but I am not convinced that it satisfies the originality clause of

WP:IUP#Diagrams and other images (see Figure 1 from the Nature article), and it is based upon SARS-CoV, not SARS-CoV-2 (the Nature article is from 2016)." The diagram this is based upon is here, and my primary concern is whether this constitutes an original image. As for whether the content is correct in the case of SARS-CoV-2, that is unclear. Our article points out that studies indicate SARS-CoV-2 does not only use the ACE2 receptor for cell entry. Although that is clearly the best-known way it enters the cell, it also seems to use BSG. I am also unsure of how this shows unzipping taking place only after entry. Doesn't uncoating take place at the point of entry to the cell? Dekimasuよ!

10:53, 28 March 2020 (UTC)

Hello! Dear @Dekimasu: Regarding to your first question about the originality of the work. One of the sources that we have used and the most important in terms of content has been the one that we reference. But the present work does not mimic the content or the aesthetic. Aesthetics is very different with respect to various graphic resources such as color (we have used a totally different palette), format and composition (given the needs of what we wanted to show, we needed a format that would help the viewer to see the flow of information from a simpler and more orderly way). On the other hand, all the elements and actions have been labeled in a different way. As for content and the elements shown, the graphic presentation is created based on the general knowledge of this virus and the commands of an expert in this field have been followed. The structure of the virus is different, all structural proteins show different shapes and HE proteins are included. As for the cycle itself, parts have been simplified, omitted and added. For example, the way the RNA is released into the cytoplasm and the nucleocapsid is dismantled. The replication and transcription steps have been greatly simplified to aid reading and information flow. The assembly is represented in another way and the maturation of the virus is explained. Parts that can draw attention in terms of their similarity are that we only have one virus in the endosome, when we could have many more, but this greatly simplifies the information and helps us to explain the graph. The order of the cycles that begins on the left and ends on the right may draw attention also, but this is the normal reading order that we have by culture and that we should not change. On the other hand, the elements that appear in the translation of polyproteins and replication-transcription complex, we decided to keep them similar to have the same visual language. And elements such as receptors or RNA-s, golgi apparatus, endoplasmatic reticulum or nucleus, are classic elements that are represented in this way in many graphs, therefore we cannot attribute them to a specific graph.

As for your second consideration: if the the information represented is correct or not. As I comment the graph is based on general information about the virus, and not on a specific article or research (you can know read the leyend that we have already translate to english). We wanted to make an approximation with a graph that shows most of the elements involved with a good quality, easy to understand and well ordenized and offer it to all the research community that is working in this area. Our intention is that it serves as a tool for new visualizations based on new discoveries, the graph is in a svg format and anybody could change it to explain his/her new descoveries or thoughts. We just wanted to offer this tool for scientific communication. Best regards. Vega — Preceding unsigned comment added by Vega asensio (talk • contribs) 09:54, 31 March 2020 (UTC)

There are many things to consider here, and I don't think that the question of whether the image is too derivative can be resolved between the two of us, so I hope there will be more comments. I do believe the image is informative and I appreciate your efforts in making it. (Please also note that the way you have termed your reply here might be understood to indicate that you are using a

shared account, which is not allowed.) However, I wanted to point out your mention of HE proteins. My understanding is that both strains of SARSr-CoV do not encode HE proteins (see this). Dekimasuよ!

07:19, 4 April 2020 (UTC)

@Dekimasu: yo! Hope you're well. I re-rewrote the lede. i opened this discussion, so if I need to re-re-rewrite it, we can discuss it here first.

I took my previous rewrite and dropped the COVID-19-related info. I don't know which parts of that copied content from that article, so I still included it in the edit's summary. I've also added some info from there that stood out to me. Like my initial rewrite, this one removed anything not in the article body.

I plan for the lede to mention the polybasic cleavage site, but I need to read the sources and write, in the article body, a brief explanation of what it is (and maybe how it contributes to virulence?). Tangentially, I recognized influenza A virus as a more closely related subject but went with Rotavirus because it's a FA. I didn't find FA on viral species/strain (alas); next time, I'll dig into the GAs and see what pops up there. Thanks for all your hard work on this article! Rotideypoc41352 (talk · contribs) 13:42, 31 March 2020 (UTC)

We appreciate the effort, but it is not clear why a full lede rewrite is necessary to begin with. Additionally, the lead rewrite is still primary about COVID-19 cases, which does not even concern this article, is much less concise, and also removes well-sourced naming information from the prior lede without reason. Symphony Regalia (talk) 22:07, 31 March 2020 (UTC)

Symphony Regalia is again edit warring over the lead, it's clear that ultimately it's coming to a

WP:NOTHERE situation. Hemiauchenia (talk

) 21:52, 31 March 2020 (UTC)

I'm following

WP:HOUNDING. Symphony Regalia (talk

) 22:07, 31 March 2020 (UTC)

(edit conflict) Thank you, EvergreenFir and Hemiauchenia, for your support. I fully accept that my rewrite serves only as one small step in teaching our readers, regardless of their worldview or where they hail from, something they didn't know about the new virus. I certainly learned a lot combing the article body as I rewrote the lede! Stay well, everyone! Rotideypoc41352 (talk · contribs) 22:34, 31 March 2020 (UTC)

I have to agree that user

WP:HOUNDING and that the rewrite was unwarranted. XavierItzm (talk

) 11:09, 1 April 2020 (UTC)

@XavierItzm: unwarranted—what makes you say that? Stay well, Rotideypoc41352 (talk · contribs) 15:32, 1 April 2020 (UTC)

Rather than just removing/reinstating the new lede, there are probably elements of both ledes that are worth retaining. It's important to think about what the new lede shows us (we should thank Rotideypoc41352 for bringing a fresh perspective). It's clear there was a reason for it: to better serve as a summary of the article, which is what the lede is supposed to do. If we don't like how the new lede turned out, then that might point us to underlying issues with the article. From my perspective, the new lede relies too much on the epidemiology of the virus. As the note in the epidemiology section states, it is intended to tell use more about the epidemiology of the virus than of how the current pandemic is progressing. In that regard, I don't find the case fatality rate or similar aspects of the pandemic to be the sorts of information that we should be trying to summarize in the lede. That data is time- and location-dependent, even if we mention it in the article, and if you look through the archives I think there are some discussions about why we removed that sort of information (it might also explain why there was a stray comment left below today [now removed] saying that we should have a chart of where the cases have taken place–the new setup seems to be misleading some readers into thinking this is more about the pandemic than it is). There are a few other objections that I have, such as how the new setup tells us what the virus does (cause COVID-19) before it tells us what it is (a single-stranded RNA virus), but the underlying point is whether the lede is serving as a summary of the text, and I have to agree that there are some ways in which the old lede wasn't. As for moving around the names, clearly what we have now is suboptimal and there should be a separate section like the one Feminist added. However, since there is a deadlock on what to do with that part of the article, leaving the status quo paragraph in the lede is probably the best option at the moment. Let's try to build on what is introduced or find compromises. Dekimasuよ! 01:39, 2 April 2020 (UTC)

With the COVID-19 information removed and the names restored, I believe the current changes are an improvement to the original rewrite and a better middle ground, but as it is now it would flow better if the 1st and 4th paragraphs were combined. In it's current state it jumps from naming/general information -> classification and origin -> epidemiology -> naming/general information, which is more jarring than it was prior to this attempt to rewrite the lede, and comes across as less professional. This also fits

WP:LEDE guidelines which indicate that alternative names should ideally be in the first paragraph. If someone wants to make a separate section I'm fine with that, but it should be something that expands on and presents a more detailed history on names in the lede/terminology, and not as a means to remove them. Symphony Regalia (talk

) 05:20, 2 April 2020 (UTC)

Whereas I still think Rotideypoc41352 original re-write was a bridge too far, I've come around to appreciate the very useful edits done afterwards by both Dekimasu and by Symphony Regalia, and I join Dekimasu in thanking Rotideypoc41352 for bringing a fresh perspective. At the end of it all, with all of the contributions, the lead as it stands right now seems quite informative and useful. XavierItzm (talk) 11:46, 2 April 2020 (UTC)

You're welcome! Rotideypoc41352 (talk · contribs) 14:40, 2 April 2020 (UTC)

I realize perhaps neither my initial statement here nor my edit summary explicitly states the reason for my rewrite. So thank you, Dekimasu, for clearing it up here! I also appreciate the detail in your critique of my rewrite and in your edit summaries. Honestly, hard to disagree with someone who's demonstrated a clear understanding of your thoughts and then addresses them directly with solid reasoning. Stay well, Rotideypoc41352 (talk · contribs) 14:40, 2 April 2020 (UTC)

Obviously the hatnote at the top of the page needs to have a link to COVID-19. We can easily do it by just linking the already existing word COVID-19, or we can add a completely new sentence, "For the actual disease caused by this virus, see COVID-19". Which would be better? Red Slash 17:39, 2 April 2020 (UTC)

@Red Slash: Obviously the hatnote...needs to...link to COVID-19—what makes you say that? Rotideypoc41352 (talk · contribs) 19:00, 2 April 2020 (UTC)

Because no one would call COVID-19 "Severe acute respiratory syndrome coronavirus 2", it is still not clear to me that this should be linked in the hatnote. Hatnotes are in place for when readers are looking for an article with a similar title. I do not see how a reader could be confused in this case. COVID-19 is linked prominently in the second sentence of the article. Dekimasuよ! 19:53, 2 April 2020 (UTC)

I think it's fairly likely that someone would end up at this article after being linked here from a search result or a link embedded in an article -- I don't feel strongly enough about it to spend the time to back this up with data, but it seems plausible to me. { ${\displaystyle \mathbb {JPG} }$ } 03:25, 9 April 2020 (UTC)