Teneurin
| Teneurin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Teneurin | ||||||||
| Pfam | PF06484 | ||||||||
| InterPro | IPR009471 | ||||||||
| Membranome | 1168 | ||||||||
| |||||||||
Teneurins are a family of
Teneurins are highly conserved between
The intracellular domain of some, if not all, teneurins can be cleaved and transported to the
There are four teneurin genes in vertebrates, named teneurin-1 through -4. Other names found in the literature include
History
Originally discovered as ten-m and ten-a in
Function
Teneurins
Additionally, they have been known to interact with the cytoskeleton adaptor protein, CAP/ponsin, suggesting cell signalling roles and regulation of actin organisation.[3]
Teneurin-3 regulates the structural and functional wiring of
Structure
Ten-m1–4, exist as homodimers and undergo homophilic interactions in
C terminal domain
The large C-terminal extracellular domain consists of eight EGF-like
N terminal domain
| Teneurin Intracellular Region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Ten_N | ||||||||
| Pfam | PF06484 | ||||||||
| InterPro | IPR009471 | ||||||||
| |||||||||
The teneurin intracellular (IC) domain (~300–400 aa) is located at the N-terminus and contains a number of conserved putative tyrosine phosphorylation sites, two EF-hand-like calcium-binding motifs, and two polyproline domains. These proline-rich stretches are characteristic of SH3-binding sites. There is considerable divergence between intracellular domains of invertebrate and vertebrate teneurins as well as between different invertebrate proteins.[5][6][7][8][9]
This domain is found in the intracellular N-terminal region of the teneurin family.
Human genes
Human genes encoded teneurin domain proteins (TENM1-4) are list in the infoboxes.
References
Further reading
- Baumgartner S, Martin D, Hagios C, Chiquet-Ehrismann R (August 1994). "Tenm, a Drosophila gene related to tenascin, is a new pair-rule gene". EMBO J. 13 (16): 3728–40. PMID 8070401.
- Levine A, Bashan-Ahrend A, Budai-Hadrian O, Gartenberg D, Menasherow S, Wides R (May 1994). "Odd Oz: a novel Drosophila pair rule gene". Cell. 77 (4): 587–98. S2CID 32035939.
- Tucker RP, Chiquet-Ehrismann R (February 2006). "Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development". Dev. Biol. 290 (2): 237–45. PMID 16406038.