ADP-ribosyl cyclase
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the chemical reaction
- NAD+ + H2O cADPR + H2O + nicotinamide ADP-ribose + nicotinamide
The 3
ADP-ribose. This makes it different from NAD+ glycohydrolase (EC 3.2.2.5), where the reaction does not proceed through cADPR.[1][2]
This enzyme belongs to the family of
nicotinate and nicotinamide metabolism
.
References
- ^ "ENZYME - 3.2.2.5 NAD(+) glycohydrolase". enzyme.expasy.org. Retrieved 2022-07-11.
- ^ "ENZYME - 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase". enzyme.expasy.org. Retrieved 2022-07-11.
- ALIVISATOS SG, WOOLLEY DW (1956). "Solubilization and purification of the diphosphopyridine nucleotidase from beef spleen". J. Biol. Chem. 219 (2): 823–32. PMID 13319302.
- ZATMAN LJ, KAPLAN NO, COLOWICK SP (1953). "Inhibition of spleen diphosphopyridine nucleotidase by nicotinamide, an exchange reaction". J. Biol. Chem. 200 (1): 197–212. PMID 13034774.
- Zatman LJ, Kaplan NO, Colowick SP, Ciotti MM (1953). "Formation of the isonicotinic acid hydrazide analog of DPN". J. Am. Chem. Soc. 75 (13): 3293–3294. .
