α-Mannosidase
(Redirected from
Alpha-Mannosidase
)
| α-Mannosidase | |||||||||
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ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.[3][4]
Isoenzymes
Humans express the following three α-mannosidase
isoenzymes
:
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Applications
It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.[5]
Pathology
A deficiency can lead to α-mannosidosis.[6]
References
External links
- GeneReviews/NCBI/NIH/UW entry on Alpha-Mannosidosis
- OMIM entries on Alpha-Mannosidosis
- alpha-Mannosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
