Alpha-enolase
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 1: 8.86 – 8.88 Mb | Chr 4: 150.32 – 150.33 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Enolase 1 (ENO1), more commonly known as alpha-enolase, is a
Structure
ENO1 is one of three enolase isoforms, the other two being
Relationship to Myc-binding protein-1
The mRNA transcript of the ENO1 gene can be alternatively translated into a
Function
As an enolase, ENO1 is a glycolytic enzyme the catalyzes the conversion of
Clinical significance
Cancer
ENO1 overexpression has been associated with multiple tumors, including
ENO1 is located on the 1p36 tumor suppressor locus near
Autoimmune disease
ENO1 has been detected in serum drawn from children diagnosed with juvenile idiopathic arthritis.[19]
Alpha-enolase has been identified as an
Gastrointestinal disease
Hemolytic anemia
Enolase deficiency is a rare inborn error of metabolism disease, leads to hemolytic anemia in affected homozygous carriers of loss of function mutations in ENO1.[25] As with other glycolysis enzyme deficiency diseases, the condition is aggravated by redox-cycling agents such as nitrofurantoin.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".
Interactions
Alpha-enolase has been shown to
See also
External links
- Alpha-Enolase Linked to Severe Asthma - medscape news report, 25 aug 2006.
- Human ENO1 genome location and ENO1 gene details page in the UCSC Genome Browser.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000074800 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063524 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "ENO1 enolase 1 (alpha)". NCBI Entrez Gene database.
- ^ PMID 26024773.
- S2CID 25167240.
- PMID 8513787.
- ^ PMID 24650096.
- ^ PMID 10681589.
- ^ PMID 23381546.
- S2CID 9191423.
- ^ PMID 23894455.
- ^ PMID 24841372.
- PMID 26870836.
- PMID 1793452.
- ^ PMID 27723749.
- ^ PMID 22895339.
- PMID 25068682.
- S2CID 11857420.
- PMID 16890761.
- PMID 12847697.
- PMID 17200661.
- PMID 16083875.
- PMID 4640298.
- PMID 11134351.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.