Bismuth subgallate
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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JSmol) | |
| Density | 1.1 g/cm3 |
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Bismuth subgallate, with a chemical formula C7H5BiO6, is commonly used to treat malodor by deodorizing
Also, a double blind study in 1974 reported its effectiveness as a flatulence/stool deodorant in ileostomy patients.[2]
Adverse effects
It can cause darkening of the tongue and stools, which is temporary.[3]
In 1974, a reversible encephalopathy was noted and examined in four colon cancer patients taking bismuth subgallate after abdominoperineal resection.[4]
Bismuth subgallate is contraindicated in case of hypersensitivity to the substance, and should be used with caution in people with liver disease or kidney disease.[3] It is grouped in pregnancy category C[3] (risk not ruled out: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks). During lactation, very little bismuth subgallate passes over to the child.[3]
Structure
Crystal structure determination of bismuth subgallate revealed it is a coordination polymer with the formula [Bi(C6H2(O)3COOH)(H2O)]n2nH2O.[5] The phenolate oxygen atoms of the gallate ligand chelate to bismuth cations and form chains. The material is nanoporous and the open-channels can be filled with small gas molecules such as carbon dioxide.[5]
See also
External links
- American Cancer Society: Ileostomy Guide [1] Archived 2007-09-29 at the Wayback Machine
- Cleveland Clinic-Having an Ileostomy– A Primer for New Ostomates [2] Archived 2012-06-16 at the Wayback Machine
- The Ostomy Files:The Issue of Oral Medications and a Fecal Ostomy [3] Archived 2012-02-06 at the Wayback Machine
- Devrom website [4]