Casein kinase 2, alpha 1
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| Location (UCSC) | Chr 20: 0.47 – 0.54 Mb | Chr 2: 152.07 – 152.12 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.[5][6]
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.[7]
Interactions
Casein kinase 2, alpha 1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000101266 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074698 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 2174700.
- PMID 1766873.
- ^ "Entrez Gene: CSNK2A1 casein kinase 2, alpha 1 polypeptide".
- PMID 11972058.
- ^ PMID 9685505.
- S2CID 11296989.
- S2CID 84600671.
- S2CID 13054364.
- ^ PMID 10799509.
- PMID 9571630.
- PMID 9188720.
- PMID 11710515.
- S2CID 257329.
- PMID 12876286.
- ^ PMID 12145206.
- PMID 10381337.
- PMID 10747897.
- PMID 11940573.
- S2CID 1093672.
- PMID 10938077.
- S2CID 25685775.
- PMID 7651819.
Further reading
- ole-MoiYoi OK (1995). "Casein kinase II in theileriosis". Science. 267 (5199): 834–6. S2CID 1894122.
- Allende JE, Allende CC (1995). "Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation". FASEB J. 9 (5): 313–23. S2CID 36327541.
- Faust M, Montenarh M (2001). "Subcellular localization of protein kinase CK2. A key to its function?". Cell Tissue Res. 301 (3): 329–40. S2CID 11394831.
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