Conformational epitope

In

An antigen is any substance that the immune system can recognize as foreign. Antigens are usually proteins that are too large to bind as a whole to any receptor so only specific segments, that form the antigen, bind with a specific receptor. Such segments are called epitopes. Likewise, it is only the paratope of the receptor that comes in contact with the epitope.

Proteins are composed of repeating

• Antigen
• Linear epitope
• Epitope mapping, finding (on an antigen protein) the epitope(s) for a specific antibody

References

• Antibody-protein interactions: benchmark datasets and prediction tools evaluation
• EpiSearch, a new method to predict conformational epitopes using phage display peptide sequences