Enterochromaffin-like cell
Enterochromaffin-like cell | |
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Details | |
Location | Gastric mucosa |
Identifiers | |
Latin | endocrinocytus ECL |
MeSH | D019861 |
TH | H3.04.02.0.00030 |
Anatomical terms of microanatomy |
Enterochromaffin-like cells or ECL cells are a type of
Function
ECL cells synthesize and secrete
However, ECL cells are activated directly by ACh on M1 receptors from direct vagal innervation leading to histamine release. This pathway will be inhibited by atropine.[2]
Gastrin is transferred from a specific type of G cell in the gastric epithelium to the ECL cells by blood. Histamine and gastrin act synergistically as the most important stimulators of hydrochloric acid secretion from parietal cells and stimulators of secretion of pepsinogen from chief cells. The most important inhibitor of the ECL cell is somatostatin from oxyntic D cells.
Enterochromaffin-like cells also produce
Clinical significance
A prolonged stimulation of these cells causes their
History
The name is derived from their location in the enteric system and their
See also
- List of distinct cell types in the adult human body
- Enterochromaffin cell
- Chromaffin cell
- List of human cell types derived from the germ layers
References
- ^ Enterochromaffin-like+Cells at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- PMID 19439804.
- PMID 20480516.