Friend virus
| Friend virus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Pararnavirae |
| Phylum: | Artverviricota |
| Class: | Revtraviricetes |
| Order: | Ortervirales |
| Family: | Retroviridae |
| Genus: | Gammaretrovirus |
| Species: | |
| Strain: | Friend virus
|
The Friend virus (FV) is a strain of
ssRNA
.
Vaccination
Experiments have shown that it is possible to protect against Friend virus infection with several types of vaccines, including
peptides, and recombinant vaccinia vectors expressing the Friend virus gene. In a study of vaccinated mice, it was possible to identify the immunological epitopes required for protection against the virus, thus determining the types of immunological responses necessary or required for protection against it. The research discovered protective epitopes that were localized to F-MuLV gag and env proteins. This was achieved using recombinant vaccinia viruses expressing the gag and env genes of FV.[citation needed
]
Implications
Friend virus models showed valuable information regarding genetic resistance to retroviral disease. A particular gene of interest is the Rfv-3 gene, which cause susceptibility to suppression of the FV specific antibody response. The greater understanding by which the mechanisms work may aid in the development of immunotherapies and vaccines that may be applicable to human diseases.[citation needed]
References
- PMID 13416470.
External links
- Hasenkrug, Kim J.; Chesebro, Bruce (1997). "Immunity to retroviral infection: The Friend virus model". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7811–6. PMID 9223268.
- Diamond, Leila (1994). Charlotte Friend 1921–1987 (PDF). Biographical Memoirs. Vol. 63.
- Santiago, ML; Montano, M; Benitez, R; Messer, RJ; Yonemoto, W; Chesebro, B; Hasenkrug, KJ; Greene, WC (2008). "Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection". Science. 321 (5894): 1343–6. PMID 18772436.
| Authority control databases: National |
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