GLIC
The GLIC receptor is a
eukaryotic homologues are hetero-oligomeric (assembled from different subunits), all until now known bacteria known to express LICs encode a single monomeric unit, indicating the GLIC to be functionally homo-oligomeric (assembled from identical subunits).[1]
The similarity of amino-acid sequence to the eukaryotic
, indicating the similar function of the GLIC to its eukaryotic equivalents. Regardless, the purpose of regulating the threshold for action potential excitation in the nerve signal transmission of multicellular organisms cannot translate to single-cell organisms, thereby not making the purpose of bacterial LGICs immediately obvious.Structure
The structure of the open channel structure was solved by two independent research teams in 2009[2][3] at low pH values of 4-4.6 (GLIC being proton-gated).
See also
- Cys-loop receptors
- Ion channel
- Receptor (biochemistry)
References
External links