GRID1
| GRID1 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 85.6 – 86.37 Mb | Chr 14: 34.54 – 35.31 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein[5][6] (1009 aa) encoded by the GRID1 gene.[7][8] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[9]
Function
This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system[10] and is important in synaptic plasticity.[7][11]
Clinical significance
Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[12][13]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000182771 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041078 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1372507.
- PMID 9828146.
- ^ a b "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1".
- PMID 10574462.
- PMID 34100982.
- S2CID 203937925.
- PMID 28110935.
- S2CID 9497500.
- S2CID 20949145.
Further reading
- Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, et al. (December 2005). "Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios". American Journal of Human Genetics. 77 (6): 918–36. PMID 16380905.
- Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (August 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. S2CID 10534933.
- Ly CD, Roche KW, Lee HK, Wenthold RJ (February 2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochemical and Biophysical Research Communications. 291 (1): 85–90. PMID 11829466.
- Roche KW, Ly CD, Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ (May 1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses". The Journal of Neuroscience. 19 (10): 3926–34. PMID 10234023.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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